Keisuke Okita

TL;DR: Results provide a technological basis to obtain functional cardiomyocytes from iPSCs and show various cardiac marker expressions, synchronized calcium transients,Cardiomyocyte-like action potentials, pharmacological reactions, and ultra-structural features as cardiomeocytes.

TL;DR: It is shown that reprogramming of elderly fibroblasts restores age-associated mitochondrial respiration defects, indicating that these aging phenotypes are reversible and are similar to differentiation phenotypes in that both are controlled by epigenetic regulation, not by mutations in either the nuclear or the mitochondrial genome.

TL;DR: The iPS cell‐derived DCs (iPS‐DCs) possessed the characteristics of DCs including the capacity of T‐cell‐stimulation, antigen‐processing and presentation and cytokine production, and DNA microarray analyses revealed the upregulation of genes related to antigen‐presenting functions during differentiation into iPS‐ DCs and similarity in gene expression profile in iPS•DCs and bone marrow cell‐ derived DCs.

TL;DR: Studies of the mechanisms underlying the reprogramming and establishment of non-integration methods contribute evidence to resolve the safety concerns associated with iPS cells.

TL;DR: The immunogenicity of allogeneic iPSC-CMs was reduced by MHC-matched transplantation although a requirement for appropriate immune suppression was retained for successful engraftment.