Keisuke Okita

TL;DR: It is proposed that iPSCs can be induced to differentiate into retinal cells which have a possibility to be used as patient-specific donor cells for transplantation therapies.

TL;DR: In this article, the authors show that reprogramming of elderly fibroblasts restores age-associated mitochondrial respiration defects, indicating that these aging phenotypes are reversible and are similar to differentiation phenotypes in that both are controlled by epigenetic regulation, not by mutations in either the nuclear or the mitochondrial genome.

TL;DR: It is demonstrated that iPSCs derived from Dox-withdrawn kidney tumor cells give rise to nonneoplastic kidney cells in mice, proving that they have not undergone irreversible genetic transformation and suggest that epigenetic regulation associated with iPSC derivation may drive development of particular types of cancer.

TL;DR: Two genome-editing strategies for making immunocompatible donor iPSCs are shown, estimated to be immunologically compatible with >90% of the world's population, greatly facilitating iPSC-based regenerative medicine applications.

TL;DR: An improved hepatic differentiation protocol was developed and compared 28 hiPSC lines originated from various somatic cells and derived using retroviruses, Sendai viruses, or episomal plasmids and found that variations in hepatic differentiate were largely attributable to donor differences, rather than to the types of the original cells.