K
Keisuke Okita
Researcher at Kyoto University
Publications - 115
Citations - 26472
Keisuke Okita is an academic researcher from Kyoto University. The author has contributed to research in topics: Induced pluripotent stem cell & Embryonic stem cell. The author has an hindex of 46, co-authored 110 publications receiving 24423 citations. Previous affiliations of Keisuke Okita include Kumamoto University & Hokkaido University.
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Journal ArticleDOI
Modeling Alzheimer’s Disease with iPSCs Reveals Stress Phenotypes Associated with Intracellular Aβ and Differential Drug Responsiveness
Takayuki Kondo,Masashi Asai,Masashi Asai,Kayoko Tsukita,Yumiko Kutoku,Yutaka Ohsawa,Yoshihide Sunada,Keiko Imamura,Naohiro Egawa,Naoki Yahata,Keisuke Okita,Kazutoshi Takahashi,Isao Asaka,Takashi Aoi,Akira Watanabe,Kaori Watanabe,Chie Kadoya,Rie Nakano,Dai Watanabe,Kei Maruyama,Osamu Hori,Satoshi Hibino,Tominari Choshi,Tatsutoshi Nakahata,Hiroyuki Hioki,Takeshi Kaneko,Motoko Naitoh,Katsuhiro Yoshikawa,Satoko Yamawaki,Shigehiko Suzuki,Ryuji Hata,Shu-ichi Ueno,Tsuneyoshi Seki,Kazuhiro Kobayashi,Tatsushi Toda,Kazuma Murakami,Kazuhiro Irie,William L. Klein,Hiroshi Mori,Takashi Asada,Ryosuke Takahashi,Nobuhisa Iwata,Shinya Yamanaka,Haruhisa Inoue +43 more
TL;DR: Differential manifestation of ER stress and DHA responsiveness may help explain variable clinical results obtained with the use of DHA treatment and suggests that DHA may in fact be effective for a subset of patients.
Journal ArticleDOI
An Efficient Nonviral Method to Generate Integration-Free Human-Induced Pluripotent Stem Cells from Cord Blood and Peripheral Blood Cells†‡§
Keisuke Okita,Tatsuya Yamakawa,Yasuko Matsumura,Yoshiko Sato,Naoki Amano,Akira Watanabe,Naoki Goshima,Shinya Yamanaka +7 more
TL;DR: A modified protocol enabling efficient iPSC induction from CD34+ cord blood cells and from peripheral blood isolated from healthy donors using these plasmid vectors is reported, which enabled the establishment of blood‐derived iPSCs from seven healthy donors ranging in age from their 20s to their 60s.
Journal ArticleDOI
Drug screening for ALS using patient-specific induced pluripotent stem cells.
Naohiro Egawa,Shiho Kitaoka,Kayoko Tsukita,Motoko Naitoh,Kazutoshi Takahashi,Takuya Yamamoto,Fumihiko Adachi,Takayuki Kondo,Keisuke Okita,Isao Asaka,Takashi Aoi,Akira Watanabe,Yasuhiro Yamada,Asuka Morizane,Jun Takahashi,Takashi Ayaki,Hidefumi Ito,Katsuhiro Yoshikawa,Satoko Yamawaki,Shigehiko Suzuki,Dai Watanabe,Hiroyuki Hioki,Takeshi Kaneko,Kouki Makioka,Koichi Okamoto,Hiroshi Takuma,Akira Tamaoka,Kazuko Hasegawa,Takashi Nonaka,Masato Hasegawa,Akihiro Kawata,Minoru Yoshida,Tatsutoshi Nakahata,Ryosuke Takahashi,Maria C. Marchetto,Fred H. Gage,Shinya Yamanaka,Haruhisa Inoue +37 more
TL;DR: The new work provides an encouraging step toward using motor neurons generated from iPSCs derived from ALS patients to learn more about what triggers the death of motor neurons in this disease and to identify new candidate drugs that may be able to slow or reverse the devastating loss ofMotor neurons.
Journal ArticleDOI
Directed and Systematic Differentiation of Cardiovascular Cells From Mouse Induced Pluripotent Stem Cells
Genta Narazaki,Hideki Uosaki,Mizue Teranishi,Keisuke Okita,Bongju Kim,Satoshi Matsuoka,Shinya Yamanaka,Jun K. Yamashita +7 more
TL;DR: The differentiation properties of iPS cells are almost completely identical to those of ES cells, which would greatly contribute to a novel understanding of i PS cell biology and the development of novel cardiovascular regenerative medicine.
Journal ArticleDOI
Human iPS cell-derived dopaminergic neurons function in a primate Parkinson’s disease model
Tetsuhiro Kikuchi,Asuka Morizane,Daisuke Doi,Hiroaki Magotani,Hirotaka Onoe,Takuya Hayashi,Hiroshi Mizuma,Sayuki Takara,Ryosuke Takahashi,Haruhisa Inoue,Satoshi Morita,Michio Yamamoto,Keisuke Okita,Masato Nakagawa,Malin Parmar,Jun Takahashi +15 more
TL;DR: This preclinical study using a primate model indicates that human iPS cell-derived dopaminergic progenitors are clinically applicable for the treatment of patients with PD.