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Keith A. Cengel
Researcher at University of Pennsylvania
Publications - 210
Citations - 12705
Keith A. Cengel is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Lung cancer & Medicine. The author has an hindex of 34, co-authored 178 publications receiving 10610 citations. Previous affiliations of Keith A. Cengel include University of Illinois at Urbana–Champaign & Hospital of the University of Pennsylvania.
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Journal ArticleDOI
Site-specific phosphorylation of the human immunodeficiency virus type-1 Rev protein accelerates formation of an efficient RNA-binding conformation.
TL;DR: It is demonstrated that phosphorylation of a recombinant human immunodeficiency virus type-1 Rev protein promotes rapid formation of an efficient RNA-binding state and the described biochemical properties of the phosphorylated protein may contribute to Rev activity and possibly to HIV-1 virulence during natural infection.
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Photodynamic Therapy and Immune Checkpoint Blockade
TL;DR: Multimodal treatment plans combining immune checkpoint inhibitors with other therapies, including photodynamic therapy (PDT), may help to expand treatment efficacy and minimize side effects.
Journal ArticleDOI
SDHB mutation carriers with malignant pheochromocytoma respond better to CVD.
Lauren Fishbein,Sivan Ben-Maimon,Stephen M. Keefe,Keith A. Cengel,Daniel A. Pryma,Arturo Loaiza-Bonilla,Douglas L. Fraker,Katherine L. Nathanson,Debbie L. Cohen +8 more
TL;DR: The clinical characteristics of a cohort of patients with malignant PCC/PGL are described and CVD-specific PFS is determined in order to make recommendations regarding clinical management.
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Five-year Long-term Outcomes of Stereotactic Body Radiation Therapy for Operable Versus Medically Inoperable Stage I Non-small-cell Lung Cancer: Analysis by Operability, Fractionation Regimen, Tumor Size, and Tumor Location.
Caitlin A. Schonewolf,M. Heskel,Abigail Doucette,Sunil Singhal,M. Frick,Eric Xanthopoulos,Eric Xanthopoulos,Michael N. Corradetti,Michael N. Corradetti,Joseph S. Friedberg,Taine T. Pechet,John P. Christodouleas,William P. Levin,Abigail T. Berman,Keith A. Cengel,Vivek Verma,Stephen M. Hahn,Stephen M. Hahn,John C. Kucharczuk,Ramesh Rengan,Ramesh Rengan,Charles B. Simone +21 more
TL;DR: SBRT has excellent, durable LC and CSS rates for early‐stage NSCLC, although inoperable patients had somewhat lower OS than operable patients, likely owing to greater comorbidities.
Journal ArticleDOI
Circulating Tumor Cells Are Associated with Recurrent Disease in Patients with Early-Stage Non-Small Cell Lung Cancer Treated with Stereotactic Body Radiotherapy.
Melissa A. Frick,Steven J. Feigenberg,S. Jean-Baptiste,L. Aguarin,A. Mendes,C. Chinniah,Samuel Swisher-McClure,Abigail T. Berman,William P. Levin,Keith A. Cengel,Stephen M. Hahn,Jay F. Dorsey,Charles B. Simone,Gary D. Kao +13 more
TL;DR: Higher pretreatment C TCs and persistence of CTCs posttreatment is significantly associated with increased risk of recurrence outside the targeted treatment site, which suggests that CTC analysis may potentially identify patients at higher risk for regional or distant recurrences and who may benefit from either systemic therapy and/or timely locoregional salvage treatment.