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Keith A. Cengel
Researcher at University of Pennsylvania
Publications - 210
Citations - 12705
Keith A. Cengel is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Lung cancer & Medicine. The author has an hindex of 34, co-authored 178 publications receiving 10610 citations. Previous affiliations of Keith A. Cengel include University of Illinois at Urbana–Champaign & Hospital of the University of Pennsylvania.
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Journal ArticleDOI
Photodynamic therapy for lung cancer and malignant pleural mesothelioma.
TL;DR: Intraoperative PDT can be safely combined with macroscopically complete surgical resection and other treatment modalities for malignant pleural mesothelioma (MPM) to improve local control and prolong survival.
Journal ArticleDOI
PTH1–34 alleviates radiotherapy-induced local bone loss by improving osteoblast and osteocyte survival
Abhishek Chandra,Tiao Lin,Tiao Lin,Mary Beth Tribble,Ji Zhu,Allison R. Altman,Wei Ju Tseng,Yejia Zhang,Sunday O. Akintoye,Keith A. Cengel,X. Sherry Liu,Ling Qin +11 more
TL;DR: The data strongly support a robust radioprotective effect of PTH on trabecular bone integrity through preserving bone formation and shed light on further investigations of an anabolic therapy for radiation-induced bone damage.
Journal ArticleDOI
Pancreatic Cancer Cell Radiation Survival and Prenyltransferase Inhibition: The Role of K-Ras
Thomas Brunner,Keith A. Cengel,Stephen M. Hahn,Junmin Wu,Douglas L. Fraker,W. Gillies McKenna,Eric J. Bernhard +6 more
TL;DR: Results show that inhibition of activated K-Ras can promote radiation killing of pancreatic carcinoma in a superadditive manner and imply that farnesyltransferase inhibitor-sensitive protein other than K- Ras may contribute to survival in the context of mutant K-ras.
Journal ArticleDOI
Pilot and Feasibility Trial Evaluating Immuno-Gene Therapy of Malignant Mesothelioma Using Intrapleural Delivery of Adenovirus-IFNα Combined with Chemotherapy.
Daniel H. Sterman,Daniel H. Sterman,Daniel H. Sterman,Evan W. Alley,James P. Stevenson,Joseph S. Friedberg,Susan Metzger,Adri Recio,Edmund K. Moon,Andrew R. Haas,Anil Vachani,Sharyn I. Katz,Jing Sun,Daniel F. Heitjan,Wei-Ting Hwang,Leslie A. Litzky,Jennifer H. Yearley,Kay See Tan,Kay See Tan,Emmanouil Papasavvas,Paul G. Kennedy,Luis J. Montaner,Keith A. Cengel,Charles B. Simone,Melissa Culligan,Corey J. Langer,Steven M. Albelda +26 more
TL;DR: The combination of intrapleural Ad.IFN, celecoxib, and chemotherapy proved safe in patients with MPM and support proceeding with a multicenter randomized clinical trial of chemo-immunogene therapy versus standard chemotherapy alone.
Journal ArticleDOI
Photodynamic therapy and the evolution of a lung-sparing surgical treatment for mesothelioma
Joseph S. Friedberg,Rosemarie Mick,Melissa Culligan,James P. Stevenson,A. Fernandes,D. Smith,Eli Glatstein,Stephen M. Hahn,Keith A. Cengel +8 more
TL;DR: RP plus PDT is a reasonable option for appropriate patients pursuing a surgical treatment for malignant pleural mesothelioma and that this procedure can serve as the backbone of surgically based multimodal treatments.