Keith Fraser

TL;DR: The in vitro antiviral properties of heparin and other closely related polysaccharides are evaluated to assess the relevance of he parin-related GAGs and other sulfated poly Saccharina japonica, chemo-enzymatically synthesized trisulfated (TriS) hepar in, and unfractionated USP-heparin as part of the pharmacopeia of potential therapeutics that target SARS-CoV-2.

TL;DR: This work demonstrates a designer DNA nanostructure that can act as a template to display multiple binding motifs with precise spatial pattern-recognition properties, and shows that this approach can confer exceptional sensing and potent viral inhibitory capabilities.

TL;DR: Results suggest that GAGs may be utilized as attachment factors for host cell entry of Zika virus as they do in other pathogenic flaviviruses.

TL;DR: It is shown that mutation sites leading to protein inactivation via tryptophan-to-glycine substitution and allowing (partial) reactivation by the subsequent addition of indole are remarkably frequent, and this important finding will dramatically impact the design of future switches and sensors built by this approach.

TL;DR: This approach provides a facile route to the use of antimicrobial enzymes on surfaces by inserting specific peptide linkers upstream of the SiBP or His-tag, and could be extended to an unrelated lytic enzyme, the endolysin PlyPH, to target Bacillus anthracis Sterne cells either in buffer or in the presence of anionic surfactants.