Paul S. Kwon

TL;DR: The in vitro antiviral properties of heparin and other closely related polysaccharides are evaluated to assess the relevance of he parin-related GAGs and other sulfated poly Saccharina japonica, chemo-enzymatically synthesized trisulfated (TriS) hepar in, and unfractionated USP-heparin as part of the pharmacopeia of potential therapeutics that target SARS-CoV-2.

TL;DR: This work demonstrates a designer DNA nanostructure that can act as a template to display multiple binding motifs with precise spatial pattern-recognition properties, and shows that this approach can confer exceptional sensing and potent viral inhibitory capabilities.

TL;DR: Several HCS-compatible, biochemical, and molecular biology-driven assays, including immunohistochemistry, RNAi, reporter gene assay, CRISPR-Cas9 system, andprotein-protein interactions are summarized to assess a variety of cellular processes, including proliferation, morphological changes, protein expression, localization, post-translational modifications, and protein-protein interaction.

TL;DR: A high‐throughput screening platform for rapid evaluation of differentiation conditions in a 3D environment is demonstrated, which will aid the development and application of 3D stem cell culture models.

TL;DR: A miniaturized, three‐dimensional hNSC culture with ReNcell VM on microarray chip platforms is developed and a high‐throughput promoter‐reporter assay system using recombinant lentiviruses on hN SC spheroids to assess cell viability, self‐renewal, and differentiation is established.