P
Pranavi Koppula
Researcher at University of Texas MD Anderson Cancer Center
Publications - 17
Citations - 3172
Pranavi Koppula is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: SLC7A11 & Cancer cell. The author has an hindex of 10, co-authored 16 publications receiving 953 citations. Previous affiliations of Pranavi Koppula include University of Texas at Austin & Tata Institute of Fundamental Research.
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Journal ArticleDOI
Cystine transporter SLC7A11/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy
TL;DR: Diverse regulatory mechanisms of SLC7A11 in cancer are summarized, ferroptosis-dependent and -independent functions of S LC7A 11 in promoting tumor development are discussed, the mechanistic basis of SLP11-induced nutrient dependency in cancer cells is explored, and therapeutic strategies to target SLC 7A11 are conceptualized.
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BAP1 links metabolic regulation of ferroptosis to tumour suppression.
Yilei Zhang,Jiejun Shi,Xiaoguang Liu,Li Feng,Zihua Gong,Zihua Gong,Pranavi Koppula,Pranavi Koppula,Kapil Sirohi,Xu Li,Xu Li,Yongkun Wei,Hyemin Lee,Li Zhuang,Gang Chen,Zhen Dong Xiao,Zhen Dong Xiao,Mien Chie Hung,Junjie Chen,Junjie Chen,Peng Huang,Peng Huang,Wei Li,Boyi Gan,Boyi Gan +24 more
TL;DR: It is shown that BAP1 suppresses SLC7A11 expression and cystine uptake, thereby promoting ferroptosis and inhibiting tumour growth and uncovering a previously unappreciated epigenetic mechanism coupling ferroPTosis to tumour suppression.
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The role of ferroptosis in ionizing radiation-induced cell death and tumor suppression.
Guang Lei,Guang Lei,Yilei Zhang,Pranavi Koppula,Xiaoguang Liu,Jie Zhang,Steven H. Lin,Steven H. Lin,Jaffer A. Ajani,Qin Xiao,Zhongxing Liao,Hui Wang,Boyi Gan +12 more
TL;DR: This study reveals a previously unrecognized link between IR and ferroptosis and indicates that further exploration of the combination of radiotherapy and FINs in cancer treatment is warranted.
Journal ArticleDOI
DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer.
Chao Mao,Xiaoguang Liu,Yilei Zhang,Guang Lei,Yuelong Yan,Hyemin Lee,Pranavi Koppula,Pranavi Koppula,Shiqi Wu,Li Zhuang,Bingliang Fang,Masha V. Poyurovsky,Kellen L. Olszewski,Boyi Gan,Boyi Gan +14 more
TL;DR: In this article, the authors show that treatment of cancer cells with GPX4 inhibitors results in acute depletion of N-carbamoyl-L-aspartate, a pyrimidine biosynthesis intermediate, with concomitant accumulation of uridine.
Journal ArticleDOI
Amino acid transporter SLC7A11/xCT at the crossroads of regulating redox homeostasis and nutrient dependency of cancer.
TL;DR: A deeper understanding of SLC7A11 in cancer metabolism may identify new therapeutic opportunities to target this important amino acid transporter for cancer treatment.