T
Tomohiro Ide
Researcher at University of Tsukuba
Publications - 51
Citations - 11362
Tomohiro Ide is an academic researcher from University of Tsukuba. The author has contributed to research in topics: Peroxisome proliferator-activated receptor & Insulin resistance. The author has an hindex of 26, co-authored 50 publications receiving 10782 citations.
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Journal ArticleDOI
The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity
Toshimasa Yamauchi,Junji Kamon,Hironori Waki,Yasuo Terauchi,Naoto Kubota,Kazuo Hara,Y. Mori,Tomohiro Ide,Kouji Murakami,Nobuyo Tsuboyama-Kasaoka,Osamu Ezaki,Y. Akanuma,Oksana Gavrilova,Charles Vinson,Marc L. Reitman,Hiroyuki Kagechika,Koichi Shudo,Madoka Yoda,Yasuko Nakano,Kazuyuki Tobe,R. Nagai,Shigeko Kimura,Motowo Tomita,Philippe Froguel,Takashi Kadowaki +24 more
TL;DR: It is concluded that decreased adiponectin is implicated in the development of insulin resistance in mouse models of both obesity and lipoatrophy and that the replenishment of adiponECTin might provide a novel treatment modality for insulin resistance and type 2 diabetes.
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Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions.
Toshimasa Yamauchi,Yasunori Nio,Toshiyuki Maki,Masaki Kobayashi,Takeshi Takazawa,Masato Iwabu,Miki Okada-Iwabu,Sachiko Kawamoto,Naoto Kubota,Tetsuya Kubota,Yusuke Ito,Junji Kamon,Atsushi Tsuchida,Katsuyoshi Kumagai,Hideki Kozono,Yusuke Hada,Hitomi Ogata,Kumpei Tokuyama,Masaki Tsunoda,Tomohiro Ide,Kouji Murakami,Motoharu Awazawa,Iseki Takamoto,Philippe Froguel,Kazuo Hara,Kazuyuki Tobe,Ryozo Nagai,Kohjiro Ueki,Takashi Kadowaki +28 more
TL;DR: Adenovirus-mediated expression of AdipoR1 and R2 in the liver of Lepr−/− mice increased AMP-activated protein kinase (AMPK) activation and peroxisome proliferator-activated receptor (PPAR)-α signaling pathways, respectively, and abolished adiponectin binding and actions, leading to insulin resistance and marked glucose intolerance in vivo.
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Overexpression of Monocyte Chemoattractant Protein-1 in Adipose Tissues Causes Macrophage Recruitment and Insulin Resistance
Nozomu Kamei,Kazuyuki Tobe,Ryo Suzuki,Mitsuru Ohsugi,Taku Watanabe,Naoto Kubota,Norie Ohtsuka-Kowatari,Katsuyoshi Kumagai,Kentaro Q. Sakamoto,Masatoshi Kobayashi,Toshimasa Yamauchi,Kohjiro Ueki,Yumiko Oishi,Satoshi Nishimura,Ichiro Manabe,Haruo Hashimoto,Yasuyuki Ohnishi,Hitomi Ogata,Kumpei Tokuyama,Masaki Tsunoda,Tomohiro Ide,Koji Murakami,Ryozo Nagai,Takashi Kadowaki +23 more
TL;DR: It is concluded that both paracrine and endocrine effects of MCP-1 may contribute to the development of insulin resistance in aP2-M CP-1 mice.
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The Mechanisms by Which Both Heterozygous Peroxisome Proliferator-activated Receptor γ (PPARγ) Deficiency and PPARγ Agonist Improve Insulin Resistance
Toshimasa Yamauchi,Junji Kamon,Hironori Waki,Koji Murakami,Kiyoto Motojima,Kajuro Komeda,Tomohiro Ide,Naoto Kubota,Yasuo Terauchi,Kazuyuki Tobe,Hiroshi Miki,Atsuko Tsuchida,Yasuo Akanuma,Ryozo Nagai,Satoshi Kimura,Takashi Kadowaki +15 more
TL;DR: It is concluded that, although by different mechanisms, both heterozygous PPARγ deficiency andPPARγ agonist improve insulin resistance, which is associated with decreased TG content of muscle/liver and prevention of adipocyte hypertrophy.
Journal ArticleDOI
Polyunsaturated fatty acids suppress sterol regulatory element-binding protein 1c promoter activity by inhibition of liver X receptor (LXR) binding to LXR response elements
Tomohiro Yoshikawa,Hitoshi Shimano,Naoya Yahagi,Tomohiro Ide,Michiyo Amemiya-Kudo,Takashi Matsuzaka,Masanori Nakakuki,Sachiko Tomita,Hiroaki Okazaki,Yoshiaki Tamura,Yoko Iizuka,Ken Ohashi,Akimitsu Takahashi,Hirohito Sone,Jun-ichi Osuga,Takanari Gotoda,Shun Ishibashi,Nobuhiro Yamada +17 more
TL;DR: The data suggest that PUFAs could be deeply involved in nutritional regulation of cellular fatty acid levels by inhibiting an LXR-SREBP-1c system crucial for lipogenesis.