J
Jun Nakayama
Researcher at Shinshu University
Publications - 311
Citations - 10785
Jun Nakayama is an academic researcher from Shinshu University. The author has contributed to research in topics: Cancer & Mucin. The author has an hindex of 54, co-authored 296 publications receiving 9986 citations. Previous affiliations of Jun Nakayama include Osaka University & Sanford-Burnham Institute for Medical Research.
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Journal ArticleDOI
Inflammasome Activation of Cardiac Fibroblasts Is Essential for Myocardial Ischemia/Reperfusion Injury
Masanori Kawaguchi,Masafumi Takahashi,Takeki Hata,Yuichiro Kashima,Fumitake Usui,Hajime Morimoto,Atsushi Izawa,Yasuko Takahashi,Junya Masumoto,Jun Koyama,Minoru Hongo,Tetsuo Noda,Jun Nakayama,Junji Sagara,Shun'ichiro Taniguchi,Uichi Ikeda +15 more
TL;DR: It is found that inflammasomes are formed by I/R and that its subsequent activation of inflamMASomes leads to interleukin-1&bgr; production, resulting in inflammatory responses such as inflammatory cell infiltration and cytokine expression in the heart.
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Natural antibiotic function of a human gastric mucin against Helicobacter pylori infection.
Masatomo Kawakubo,Yuki Ito,Yukie Okimura,Motohiro Kobayashi,Motohiro Kobayashi,Kyoko Sakura,Susumu Kasama,Michiko N. Fukuda,Minoru Fukuda,Tsutomu Katsuyama,Jun Nakayama +10 more
TL;DR: The unique O-glycans in gastric mucin appeared to function as a natural antibiotic, protecting the host from H. pylori infection.
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Novel Sulfated Lymphocyte Homing Receptors and Their Control by a Core1 Extension β1,3-N-Acetylglucosaminyltransferase
Jiunn-Chern Yeh,Nobuyoshi Hiraoka,Bronislawa Petryniak,Jun Nakayama,Lesley G. Ellies,David Rabuka,Ole Hindsgaul,Jamey D. Marth,John B. Lowe,Minoru Fukuda +9 more
TL;DR: Core1-beta 3GlcNAcT and its cognate extended core1 O-glycans are identified as essential participants in the expression of the MECA-79-positive, HEV-specific L-selectin ligands required for lymphocyte homing.
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Macular corneal dystrophy type I and type II are caused by distinct mutations in a new sulphotransferase gene.
Tomoya O. Akama,Kohji Nishida,Kohji Nishida,Jun Nakayama,Jun Nakayama,Hitoshi Watanabe,Kouichi Ozaki,Takahiro Nakamura,Atsuyoshi Dota,Satoshi Kawasaki,Yoshitsugu Inoue,Naoyuki Maeda,Shuji Yamamoto,Tsutomu Fujiwara,Eugene J.-M.A. Thonar,Yoshikazu Shimomura,Shigeru Kinoshita,Akira Tanigami,Michiko N. Fukuda +18 more
TL;DR: A new carbohydrate sulphotransferase gene (CHST6), encoding an enzyme designated corneal N-acetylglucosamine-6-sulphotranferase (C-GlcNAc6ST), is identified within the critical region of MCD type I, suggesting that mutations found in type II lead to loss of cornea-specific expression of CHST6.
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Expression cloning of a human polysialyltransferase that forms the polysialylated neural cell adhesion molecule present in embryonic brain.
TL;DR: The results indicate that the cloned polysialyltransferase forms polysialsialylated, embryonic N-CAM, which is critical for plasticity of neural cells.