K
Kevin Ryan
Researcher at City College of New York
Publications - 72
Citations - 4217
Kevin Ryan is an academic researcher from City College of New York. The author has contributed to research in topics: Indole test & Cleavage factor. The author has an hindex of 27, co-authored 71 publications receiving 3711 citations. Previous affiliations of Kevin Ryan include City University of New York & Columbia University.
Papers
More filters
Journal ArticleDOI
Structure Based Drug Design of Crizotinib (PF-02341066), a Potent and Selective Dual Inhibitor of Mesenchymal–Epithelial Transition Factor (c-MET) Kinase and Anaplastic Lymphoma Kinase (ALK)
J. Jean Cui,Michelle Tran-Dubé,Hong Shen,Nambu Mitchell David,Pei-Pei Kung,Pairish Mason Alan,Jia Lei,Jerry Meng,Funk Lee Andrew,Botrous Iriny,Michele McTigue,Neil Grodsky,Kevin Ryan,Ellen Padrique,Gordon Alton,Sergei Timofeevski,Shinji Yamazaki,Qiuhua Li,Helen Y. Zou,James G. Christensen,Barbara Mroczkowski,Steve Bender,Robert Steven Kania,Martin Paul Edwards +23 more
TL;DR: A novel 2-amino-5-aryl-3-benzyloxypyridine series was created to more effectively make the key interactions achieved with 3, which demonstrated potent in vitro and in vivo c-MET kinase and ALK inhibition, effective tumor growth inhibition, and good pharmaceutical properties.
Journal ArticleDOI
Rolling Circle DNA Synthesis: Small Circular Oligonucleotides as Efficient Templates for DNA Polymerases
TL;DR: It is reported that small, single-stranded circular DNA oligonucleotides 26 to 74 nucleotides in size can behave as catalytic templates for DNA synthesis by several DNA polymerase enzymes, and it is demonstrated that the multimeric products can be cleaved enzymatically to short, sequence-defined oligodeoxynucleotide.
Journal ArticleDOI
Symplekin and xGLD-2 are required for CPEB-mediated cytoplasmic polyadenylation.
TL;DR: Two new factors that are essential for polyadenylation are defined: symplekin, a CPEB and CPSF binding protein that serves as a scaffold upon which regulatory factors are assembled, and xGLD-2, an unusual poly(A) polymerase that is anchored to CPEb and CPSf even before polyadenyation begins.
Journal ArticleDOI
Discovery of Ketone-Based Covalent Inhibitors of Coronavirus 3CL Proteases for the Potential Therapeutic Treatment of COVID-19.
Robert Louis Hoffman,Robert Steven Kania,Jay F. Davies,Rose Ann Ferre,Ketan S. Gajiwala,Mingying He,Robert J. Hogan,Kirk Kozminski,Lilian Y. Li,Jonathan W. Lockner,Jihong Lou,Michelle T. Marra,Lennert J. Mitchell,Brion W. Murray,James A. Nieman,Stephen Noell,Simon Paul Planken,Thomas Rowe,Kevin Ryan,George J. Smith,James Solowiej,Claire M. Steppan,Barbara Taggart +22 more
TL;DR: Preclinical experiments reveal 4 (PF-00835231) as a potent inhibitor of CoV-2 3CLpro with suitable pharmaceutical properties to warrant further development as an intravenous treatment for COVID-19.
Journal ArticleDOI
Phosphorylation of CPEB by Eg2 mediates the recruitment of CPSF into an active cytoplasmic polyadenylation complex.
TL;DR: It is demonstrated that the molecular function of Eg2-phosphorylated CPEB is to recruit CPSF into an active cytoplasmic polyadenylation complex.