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Kimberly N. Scobie
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 20
Citations - 3036
Kimberly N. Scobie is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Nucleus accumbens & Chromatin. The author has an hindex of 17, co-authored 20 publications receiving 2636 citations. Previous affiliations of Kimberly N. Scobie include Columbia University Medical Center & Allen Institute for Brain Science.
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Journal ArticleDOI
Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation.
Amar Sahay,Kimberly N. Scobie,Alexis S. Hill,C. O'Carroll,Mazen A. Kheirbek,Nesha S. Burghardt,André A. Fenton,Alex Dranovsky,René Hen +8 more
TL;DR: It is shown that inducible genetic expansion of the population of adult-born neurons through enhancing their survival improves performance in a specific cognitive task in which two similar contexts need to be distinguished, which is indicative of enhanced pattern separation.
Journal ArticleDOI
Circuit-wide Transcriptional Profiling Reveals Brain Region-Specific Gene Networks Regulating Depression Susceptibility
Rosemary C. Bagot,Hannah M. Cates,Immanuel Purushothaman,Zachary S. Lorsch,Deena M. Walker,Junshi Wang,Xiaojie Huang,Oliver M. Schlüter,Ian Maze,Catherine J J. Peña,Elizabeth A. Heller,Orna Issler,Minghui Wang,Won-Min Song,Jason L. Stein,Xiaochuan Liu,Marie A. Doyle,Kimberly N. Scobie,HaoSheng Sun,Rachael L. Neve,Daniel H. Geschwind,Yan Dong,Li Shen,Bin Zhang,Eric J. Nestler +24 more
TL;DR: This study reveals novel transcriptional networks that control stress susceptibility and offers fundamentally new leads for antidepressant drug discovery.
Journal ArticleDOI
β-catenin mediates stress resilience through Dicer1/microRNA regulation
Caroline Dias,Jian Feng,HaoSheng Sun,Ning Y.i. Shao,Michelle S. Mazei-Robison,Diane M. Damez-Werno,Kimberly N. Scobie,Rosemary C. Bagot,Benoit Labonté,Efrain Ribeiro,Xiaochuan Liu,Pamela J. Kennedy,Vincent Vialou,Deveroux Ferguson,Catherine Jensen Pena,Erin S. Calipari,Ja W.ook Koo,Ezekiell Mouzon,Subroto Ghose,Carol A. Tamminga,Rachael L. Neve,Li Shen,Eric J. Nestler +22 more
TL;DR: The authors showed that β-catenin mediates proresilient and anxiolytic effects in the nucleus accumbens, a key brain reward region, an effect mediated by D2-type medium spiny neurons.
Journal ArticleDOI
BDNF Is a Negative Modulator of Morphine Action
Ja Wook Koo,Michelle S. Mazei-Robison,Dipesh Chaudhury,Barbara Juarez,Quincey LaPlant,Deveroux Ferguson,Jian Feng,HaoSheng Sun,Kimberly N. Scobie,Diane M. Damez-Werno,Marshall Crumiller,Yoshinori N. Ohnishi,Yoko H. Ohnishi,Ezekiell Mouzon,David M. Dietz,Mary Kay Lobo,Rachael L. Neve,Scott J. Russo,Ming-Hu Han,Eric J. Nestler +19 more
TL;DR: Insight is provided into the molecular basis of morphine-induced neuroadaptations in the brain’s reward circuitry and numerous genes in the NAc, a major target region of VTA DA neurons, whose regulation by BDNF in the context of chronic morphine exposure mediated this counteractive function.
Journal ArticleDOI
Rac1 is essential in cocaine-induced structural plasticity of nucleus accumbens neurons
David M. Dietz,HaoSheng Sun,Mary Kay Lobo,Michael E. Cahill,Benjamin Chadwick,Virginia Gao,Ja Wook Koo,Michelle S. Mazei-Robison,Caroline Dias,Ian Maze,Diane M. Damez-Werno,Karen C. Dietz,Kimberly N. Scobie,Deveroux Ferguson,Daniel J. Christoffel,Yoko H. Ohnishi,Georgia E. Hodes,Yi Zheng,Rachael L. Neve,Klaus M. Hahn,Scott J. Russo,Eric J. Nestler +21 more
TL;DR: It is shown that repeated exposure to cocaine negatively regulates the active form of Rac1, a small GTPase that controls actin remodeling in other systems, and that Rac1 signaling mediates structural and behavioral plasticity in response to cocaine exposure.