K
Kira S. Makarova
Researcher at National Institutes of Health
Publications - 261
Citations - 54191
Kira S. Makarova is an academic researcher from National Institutes of Health. The author has contributed to research in topics: CRISPR & Genome. The author has an hindex of 96, co-authored 235 publications receiving 43747 citations. Previous affiliations of Kira S. Makarova include Rutgers University & San Sebastián University.
Papers
More filters
Journal ArticleDOI
The complete genome of hyperthermophile Methanopyrus kandleri AV19 and monophyly of archaeal methanogens
Alexei I. Slesarev,Katja V. Mezhevaya,Kira S. Makarova,Nikolai Polushin,Olga V. Shcherbinina,Vera V. Shakhova,Galina I. Belova,L. Aravind,Darren A. Natale,Igor B. Rogozin,Roman L. Tatusov,Yuri I. Wolf,Karl O. Stetter,Andrei Malykh,Eugene V. Koonin,Sergei A. Kozyavkin +15 more
TL;DR: The complete sequence of the GC-rich genome of Methanopyrus kandleri is determined by using a whole direct genome sequencing approach and indicates that archaeal methanogens are monophyletic.
Journal ArticleDOI
Prokaryotic homologs of Argonaute proteins are predicted to function as key components of a novel system of defense against mobile genetic elements
TL;DR: The hypothesis that pAgos are key components of a novel proKaryotic immune system that employs guide RNA or DNA molecules to degrade nucleic acids of invading mobile elements implies a functional analogy with the prokaryotic CASS and a direct evolutionary connection with eukaryotic RNAi.
Journal ArticleDOI
Evolutionary Genomics of Lactic Acid Bacteria
TL;DR: The lactic acid bacteria (LAB) might be the most numerous group of bacteria linked to humans and are naturally associated with mucosal surfaces, particularly the gastrointestinal tract, and are also indigenous to food-related habitats.
Journal ArticleDOI
Abundance of type I toxin–antitoxin systems in bacteria: searches for new candidates and discovery of novel families
Elizabeth M. Fozo,Kira S. Makarova,Svetlana A. Shabalina,Natalya Yutin,Eugene V. Koonin,Gisela Storz +5 more
TL;DR: These searches substantially expanded the collection of predicted type I toxins, revealed homology of the Ldr and Fst toxins, and suggested that type I toxin–antitoxin loci are not spread by horizontal gene transfer.
Journal ArticleDOI
Comparative Genomics of the Archaea (Euryarchaeota): Evolution of Conserved Protein Families, the Stable Core, and the Variable Shell
Kira S. Makarova,L. Aravind,L. Aravind,Michael Y. Galperin,Nick V. Grishin,Roman L. Tatusov,Yuri I. Wolf,Eugene V. Koonin +7 more
TL;DR: A comparison of the protein sequences encoded in the four euryarchaeal species whose genomes have been sequenced completely revealed 1326 orthologous sets, of which 543 are represented in all four species.