K
Kira S. Makarova
Researcher at National Institutes of Health
Publications - 261
Citations - 54191
Kira S. Makarova is an academic researcher from National Institutes of Health. The author has contributed to research in topics: CRISPR & Genome. The author has an hindex of 96, co-authored 235 publications receiving 43747 citations. Previous affiliations of Kira S. Makarova include Rutgers University & San Sebastián University.
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Journal ArticleDOI
Structural Basis for a Dual Function ATP Grasp Ligase That Installs Single and Bicyclic ω-Ester Macrocycles in a New Multicore RiPP Natural Product.
Gengxiang Zhao,Dalibor Kosek,Hong-Bing Liu,Shannon I. Ohlemacher,Brittney Blackburne,Anastasia N. Nikolskaya,Kira S. Makarova,Jiadong Sun,Clifton E. Barry,Eugene V. Koonin,Fred Dyda,Carole A. Bewley +11 more
TL;DR: Chryseoviridin, a new type of multicore RiPP encoded by Chryseobacterium gregarium DS19109 (Phylum Bacteroidetes), was characterized in this paper.
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Cellular homologs of the double jelly-roll major capsid proteins clarify the origins of an ancient virus kingdom
TL;DR: The results of this work indicate that virus kingdoms Bamfordvirae, with the DJR-MCPs, and Helvetiavirae that possess two SJRs, have distinct origins, suggesting a reappraisal of the realm Varidnaviria.
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Evolution of Genome Architecture in Archaea: Spontaneous Generation of a New Chromosome in Haloferax volcanii.
Darya Ausiannikava,Laura M. Mitchell,Hannah Marriott,Victoria Smith,Michelle Hawkins,Kira S. Makarova,Eugene V. Koonin,Conrad A. Nieduszynski,Thorsten Allers +8 more
TL;DR: This work reports an example of the third scenario: the multi-origin chromosome of the archaeon Haloferax volcanii has split into two elements via homologous recombination, which generated two new chromosomes.
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Evolution of Type IV CRISPR-Cas Systems: Insights from CRISPR Loci in Integrative Conjugative Elements of Acidithiobacillia.
Ana Moya-Beltrán,Kira S. Makarova,Lillian G. Acuña,Yuri I. Wolf,Paulo C. Covarrubias,Sergey Anatolievich Shmakov,Cristian Silva,Igor Tolstoy,D Barrie Johnson,Eugene V. Koonin,Raquel Quatrini +10 more
TL;DR: Type IV CRISPR-Cas as discussed by the authors are a distinct variety of highly derived CRISpr-Cas systems that appear to have evolved from type III systems through the loss of the target-cleaving nuclease and partial deterministic deterministic decoder.
Posted ContentDOI
CRISPRIdentify: Identification of CRISPR arrays using machine learning approach
Alexander Mitrofanov,Omer S. Alkhnbashi,Sergey Shmakov,Kira S. Makarova,Eugene V. Koonin,Rolf Backofen +5 more
TL;DR: This work introduces a data-driven approach that uses machine learning to detect and differentiate true CRISPR arrays from false ones based on several features and produces a certainty score as a practical measure of the likelihood that a given genomic region is aCRISPR array.