K
Kira S. Makarova
Researcher at National Institutes of Health
Publications - 261
Citations - 54191
Kira S. Makarova is an academic researcher from National Institutes of Health. The author has contributed to research in topics: CRISPR & Genome. The author has an hindex of 96, co-authored 235 publications receiving 43747 citations. Previous affiliations of Kira S. Makarova include Rutgers University & San Sebastián University.
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Two new families of the FtsZ-tubulin protein superfamily implicated in membrane remodeling in diverse bacteria and archaea
TL;DR: Methods for distant protein sequence similarity detection, phylogenetic approaches, and genome context analysis are applied to described two previously unnoticed families of the FtsZ-tubulin superfamily of bacteria and archaea.
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Phyletic Distribution and Lineage-Specific Domain Architectures of Archaeal Two-Component Signal Transduction Systems.
TL;DR: An updated census of more than 2,000 histidine kinases and response regulators encoded in 218 complete archaeal genomes, as well as unfinished genomes available from metagenomic data is provided.
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A non-canonical multisubunit RNA polymerase encoded by a giant bacteriophage.
Maria Yakunina,Maria Yakunina,T. O. Artamonova,Sergei Borukhov,Sergei Borukhov,Kira S. Makarova,Konstantin Severinov,Konstantin Severinov,Konstantin Severinov,Leonid Minakhin,Leonid Minakhin +10 more
TL;DR: The phiKZ RNAP lacks identifiable assembly and promoter specificity subunits/factors characteristic for eukaryal, archaeal and bacterial RNAPs and thus provides a unique model for comparative analysis of the mechanism, regulation and evolution of this important class of enzymes.
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Identification and Functional Verification of Archaeal-Type Phosphoenolpyruvate Carboxylase, a Missing Link in Archaeal Central Carbohydrate Metabolism
Thijs J. G. Ettema,Kira S. Makarova,Gera L. Jellema,Hinco J. Gierman,Eugene V. Koonin,Martijn A. Huynen,Willem M. de Vos,John van der Oost +7 more
TL;DR: The newly identified atPEPC, with its distinct properties, constitutes yet another example of the versatility of the enzymes of the central carbon metabolic pathways in the archaeal domain.
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Antimicrobial Peptides, Polymorphic Toxins, and Self-Nonself Recognition Systems in Archaea: an Untapped Armory for Intermicrobial Conflicts.
TL;DR: This work confidently predicts that more than 1,600 archaeal proteins, currently annotated as “hypothetical” in public databases, are components of conflict and self-versus-nonself discrimination systems.