S
Sergei A. Kozyavkin
Researcher at Russian Academy of Sciences
Publications - 26
Citations - 2648
Sergei A. Kozyavkin is an academic researcher from Russian Academy of Sciences. The author has contributed to research in topics: DNA & Gene. The author has an hindex of 16, co-authored 26 publications receiving 2471 citations. Previous affiliations of Sergei A. Kozyavkin include National Academy of Sciences of Ukraine & Laboratory of Molecular Biology.
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Journal ArticleDOI
Comparative genomics of the lactic acid bacteria
Kira S. Makarova,Alexei I. Slesarev,Yuri I. Wolf,Alexander V. Sorokin,Boris Mirkin,Eugene V. Koonin,Andrey R. Pavlov,Nadezhda Pavlova,Valeri N. Karamychev,N. N. Polouchine,V. V. Shakhova,Igor V. Grigoriev,Yunian Lou,D. Rohksar,Susan Lucas,Katherine H. Huang,David Goodstein,Trevor Hawkins,V. Plengvidhya,V. Plengvidhya,Dennis L. Welker,Joanne E. Hughes,Yong Jun Goh,Andrew K. Benson,K. A. Baldwin,Ju-Hoon Lee,I. Diaz-Muniz,B. Dosti,Vladimir V. Smeianov,W. Wechter,Ravi D. Barabote,Graciela L. Lorca,Eric Altermann,Rodolphe Barrangou,Balasubramanian Ganesan,Y. Xie,Helen Rawsthorne,Diana I. Tamir,C. Parker,Frederick Breidt,Frederick Breidt,Jeffery R. Broadbent,Robert W. Hutkins,Daniel J. O'Sullivan,J. L. Steele,Gülhan Ünlü,Milton H. Saier,Todd R. Klaenhammer,Paul G. Richardson,Sergei A. Kozyavkin,Bart C. Weimer,David A. Mills +51 more
TL;DR: Phylogenetic analyses, comparison of gene content across the group, and reconstruction of ancestral gene sets indicate a combination of extensive gene loss and key gene acquisitions via horizontal gene transfer during the coevolution of lactic acid bacteria with their habitats.
Journal ArticleDOI
The complete genome of hyperthermophile Methanopyrus kandleri AV19 and monophyly of archaeal methanogens
Alexei I. Slesarev,Katja V. Mezhevaya,Kira S. Makarova,Nikolai Polushin,Olga V. Shcherbinina,Vera V. Shakhova,Galina I. Belova,L. Aravind,Darren A. Natale,Igor B. Rogozin,Roman L. Tatusov,Yuri I. Wolf,Karl O. Stetter,Andrei Malykh,Eugene V. Koonin,Sergei A. Kozyavkin +15 more
TL;DR: The complete sequence of the GC-rich genome of Methanopyrus kandleri is determined by using a whole direct genome sequencing approach and indicates that archaeal methanogens are monophyletic.
Journal ArticleDOI
Comparative genomic analysis of the gut bacterium Bifidobacterium longum reveals loci susceptible to deletion during pure culture growth
Ju-Hoon Lee,Valeri N. Karamychev,Sergei A. Kozyavkin,David A. Mills,Andrey R. Pavlov,Nadezhda Pavlova,N. N. Polouchine,Paul G. Richardson,V. V. Shakhova,Alexei I. Slesarev,Bart C. Weimer,Daniel J. O'Sullivan +11 more
TL;DR: Deletion of genomic regions allows bifidobacteria to adapt to fermentation environments in a very rapid manner and the concomitant loss of possible competitive abilities in the gut.
Journal ArticleDOI
Recent developments in the optimization of thermostable DNA polymerases for efficient applications.
TL;DR: The development of genetically modified DNA polymerases, which could provide significant advantages over their natural counterparts that are used today, would have an immediate impact on the efficiency and accuracy of DNA amplification applications essential to the success of the Human Genome Initiative.
Journal ArticleDOI
DNA topoisomerase V is a relative of eukaryotic topoisomerase I from a hyperthermophilic prokaryote
Alexei I. Slesarev,Karl O. Stetter,James A. Lake,Martin Gellert,Regis Krah,Sergei A. Kozyavkin,Sergei A. Kozyavkin,Sergei A. Kozyavkin +7 more
TL;DR: The findings support the idea that some essential parts of the eukaryotic transcription–translation and replication machineries were in place before the emergence of eukARYotes, and that the closest living relatives of eUKaryotes may be hyperthermophiles.