K
Kirsten H. Limesand
Researcher at University of Arizona
Publications - 55
Citations - 1853
Kirsten H. Limesand is an academic researcher from University of Arizona. The author has contributed to research in topics: Salivary gland & Saliva. The author has an hindex of 21, co-authored 49 publications receiving 1420 citations.
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Journal ArticleDOI
Clinical management of salivary gland hypofunction and xerostomia in head-and-neck cancer patients: successes and barriers
Arjan Vissink,James B. Mitchell,Bruce J. Baum,Kirsten H. Limesand,Siri Beier Jensen,Philip C. Fox,Linda S. Elting,Johannes A. Langendijk,Robert P. Coppes,Mary E. Reyland +9 more
TL;DR: This review addresses the pathophysiology underlying irradiation damage to salivary gland tissue, the consequences of radiation injury, and issues contributing to the clinical management of salivARY gland hypofunction and xerostomia.
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Sensitivity of Salivary Glands to Radiation: from Animal Models to Therapies
TL;DR: Clinical implications of radiosensitivity in normal salivary glands are discussed, animal models used to investigate radiation-inducedSalivary gland damage are compared, therapeutic advances are addressed, and future directions in the field are project.
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Radiation-induced salivary gland dysfunction results from p53-dependent apoptosis.
TL;DR: Apoptosis in the salivary glands after therapeutic head-and-neck irradiation is mediated by p53 and corresponds to Salivary gland dysfunction in vivo.
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Salivary Gland Hypofunction and Xerostomia in Head and Neck Radiation Patients.
TL;DR: Intensity-modulated radiation therapy (IMRT), and its next step, proton therapy, have the greatest potential as a management strategy for permanently preserving salivary gland function in head and neck cancer patients.
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Lifespan-extending caloric restriction or mTOR inhibition impair adaptive immunity of old mice by distinct mechanisms
Emily L. Goldberg,Melissa J. Romero-Aleshire,Kristin R. Renkema,Melissa S. Ventevogel,Wade M. Chew,Jennifer L. Uhrlaub,Megan J. Smithey,Kirsten H. Limesand,Gregory D. Sempowski,Heddwen L. Brooks,Janko Nikolich-Žugich +10 more
TL;DR: It is concluded that neither rapa feeding nor CR, in the current form/administration regimen, may be optimal strategies for extending healthy immune function and, with it, lifespan.