M
Mary E. Reyland
Researcher at Anschutz Medical Campus
Publications - 76
Citations - 4457
Mary E. Reyland is an academic researcher from Anschutz Medical Campus. The author has contributed to research in topics: Protein kinase C & Protein kinase A. The author has an hindex of 34, co-authored 72 publications receiving 4116 citations. Previous affiliations of Mary E. Reyland include Stony Brook University & VCU Medical Center.
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Journal ArticleDOI
Protein kinase C isozymes and the regulation of diverse cell responses
Edward C. Dempsey,Edward C. Dempsey,Alexandra C. Newton,Daria Mochly-Rosen,Alan P. Fields,Mary E. Reyland,Paul A. Insel,Robert O. Messing +7 more
TL;DR: New ideas on mechanisms that regulate PKC activity, including the identification of a novel PKC kinase, 3-phosphoinositide-dependent kinase-1 (PDK-1), that regulates phosphorylation of PKC, have been advanced and opposing roles for selected isozymes in the same cell system have been defined.
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Clinical management of salivary gland hypofunction and xerostomia in head-and-neck cancer patients: successes and barriers
Arjan Vissink,James B. Mitchell,Bruce J. Baum,Kirsten H. Limesand,Siri Beier Jensen,Philip C. Fox,Linda S. Elting,Johannes A. Langendijk,Robert P. Coppes,Mary E. Reyland +9 more
TL;DR: This review addresses the pathophysiology underlying irradiation damage to salivary gland tissue, the consequences of radiation injury, and issues contributing to the clinical management of salivARY gland hypofunction and xerostomia.
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Protein kinase C delta is essential for etoposide-induced apoptosis in salivary gland acinar cells.
TL;DR: It is reported that apoptosis results in the caspase-dependent cleavage of protein kinase C-δ (PKCδ) to a 40-kDa fragment, the appearance of which correlates with a 9-fold increase in PKCδ activity.
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Protein kinase C isoforms: Multi-functional regulators of cell life and death.
TL;DR: The essential role of this kinase family in both cell survival and apoptosis suggests that specific isoforms may function as molecular sensors, promoting cell survival or cell death depending on environmental cues.
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Nuclear import of PKCδ is required for apoptosis: identification of a novel nuclear import sequence
TL;DR: The results indicate that PKCδ regulates an essential nuclear event(s) that is required for initiation of the apoptotic pathway.