K
Klaus I. Matthaei
Researcher at Australian National University
Publications - 136
Citations - 10763
Klaus I. Matthaei is an academic researcher from Australian National University. The author has contributed to research in topics: Interleukin 5 & Eosinophil. The author has an hindex of 53, co-authored 136 publications receiving 10283 citations. Previous affiliations of Klaus I. Matthaei include King Saud University & King Khalid University.
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Journal ArticleDOI
Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model.
TL;DR: Results indicate that IL-5 and eosinophils are central mediators in the pathogenesis of allergic lung disease.
Journal ArticleDOI
IL-5-Deficient Mice Have a Developmental Defect in CD5+ B-1 Cells and Lack Eosinophilia but Have Normal Antibody and Cytotoxic T Cell Responses
Manfred Kopf,Frank Brombacher,Philip D. Hodgkin,Alistair J. Ramsay,Elizabeth A. Milbourne,Wen J Dai,K.S. Ovington,Carolyn A. Behm,Georges Köhler,Ian G. Young,Klaus I. Matthaei +10 more
TL;DR: Mice deficient in interleukin-5 (IL-5-/- mice) were generated by gene targeting in embryonal stem cells, indicating that increased eosinophils do not play a significant role in the host defence in this parasite model.
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The role of interleukin-6 in mucosal IgA antibody responses in vivo
Alistair J. Ramsay,Alan J. Husband,Ian A. Ramshaw,Shisan Bao,Klaus I. Matthaei,Georges Koehler,Manfred Kopf +6 more
TL;DR: A critical role for IL-6 in vivo in the development of local IgA antibody responses is demonstrated and the effectiveness of vector-directed cytokine gene therapy is illustrated.
Journal ArticleDOI
Histone variant H2A.Z is required for early mammalian development.
Renate Faast,Varaporn Thonglairoam,Thomas C. Schulz,Jacquie Beall,Julian R.E. Wells,Helen Taylor,Klaus I. Matthaei,Peter D. Rathjen,David J. Tremethick,Ian Lyons +9 more
TL;DR: It is shown for the first time that a mammalian histone variant, H2A.Z, plays a critical role in early development, and it is concluded that this hist one variant plays a pivotal role in establishing the chromatin structures required for the complex patterns of gene expression essential for normal mammalian development.
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Relationship between interleukin-5 and eotaxin in regulating blood and tissue eosinophilia in mice.
TL;DR: It is proposed that eotaxin secreted from inflamed tissue may play an important role in initiating both blood and tissue eosinophilia in the early phases of allergic inflammation.