K
Klaus M. Hahn
Researcher at University of North Carolina at Chapel Hill
Publications - 215
Citations - 16976
Klaus M. Hahn is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: RHOA & Proto-oncogene tyrosine-protein kinase Src. The author has an hindex of 61, co-authored 210 publications receiving 15343 citations. Previous affiliations of Klaus M. Hahn include University of California, Berkeley & University of California, San Diego.
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Journal ArticleDOI
Patterns of elevated free calcium and calmodulin activation in living cells
TL;DR: It is reported here that the rise in free calcium and MeroCaM activation occur in the same period during serum stimulation of quiescent fibroblasts and correlates with the spatial pattern of increasedfree calcium and the contraction of transverse fibres during wound healing.
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Spatial and Temporal Analysis of Rac Activation during Live Neutrophil Chemotaxis
Elisabeth Gardiner,Kersi Pestonjamasp,Benjamin P. Bohl,Chester E. Chamberlain,Klaus M. Hahn,Gary M. Bokoch +5 more
TL;DR: Data establish that Rac GTPase is spatially and temporally regulated to coordinate leading-edge extension and tail retraction during a complex motile response, the chemotaxis of human neutrophils.
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Engineering extrinsic disorder to control protein activity in living cells.
Onur Dagliyan,Miroslaw Tarnawski,Pei Hsuan Chu,David Shirvanyants,Ilme Schlichting,Nikolay V. Dokholyan,Klaus M. Hahn +6 more
TL;DR: The authors engineered domains into three different classes of proteins involved in cell signaling and found that switching the proteins between active and inactive states could control the shape and movement of living cells.
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Designing photoswitchable peptides using the AsLOV2 domain
TL;DR: It is shown that the genetically encoded light-sensitive LOV2 domain of Avena Sativa phototropin 1 (AsLOV2) can be used to reversibly photomodulate the affinity of peptides for their binding partners.
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Tpr is localized within the nuclear basket of the pore complex and has a role in nuclear protein export
TL;DR: It is determined that mammalian Tpr is concentrated within the nuclear basket of the pore complex in a distribution similar to Nup153 and Nup98 and is a nucleoporin of thenuclear basket with a role in nuclear protein export.