K
Klaus M. Hahn
Researcher at University of North Carolina at Chapel Hill
Publications - 215
Citations - 16976
Klaus M. Hahn is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: RHOA & Proto-oncogene tyrosine-protein kinase Src. The author has an hindex of 61, co-authored 210 publications receiving 15343 citations. Previous affiliations of Klaus M. Hahn include University of California, Berkeley & University of California, San Diego.
Papers
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Journal ArticleDOI
Amiloride inhibits macropinocytosis by lowering submembranous pH and preventing Rac1 and Cdc42 signaling (Journal of Cell Biology (2010) 188, (547-563))
Journal ArticleDOI
Coordination by Cdc42 of Actin, Contractility, and Adhesion for Melanoblast Movement in Mouse Skin
Emma F. Woodham,Nikki R. Paul,Benjamin J. Tyrrell,Heather J. Spence,Karthic Swaminathan,Michelle R. Scribner,Evangelos Giampazolias,Ann Hedley,William Clark,Frieda Kage,Daniel J. Marston,Klaus M. Hahn,Stephen W.G. Tait,Lionel Larue,Cord Brakebusch,Robert H. Insall,Laura M. Machesky +16 more
TL;DR: It is shown that RhoA is redundant in the melanocyte lineage but that Cdc42 coordinates multiple motility systems independent of Rac1, and that loss of CDC42 de-coupled three main systems: actin assembly via the formin FMNL2 and Arp2/3, active myosin-II localization, and integrin-based adhesion dynamics.
Journal ArticleDOI
Spatiotemporal dynamics of GEF-H1 activation controlled by microtubule- and Src-mediated pathways.
Mihai L. Azoitei,Jungsik Noh,Daniel J. Marston,Philippe Roudot,Christopher B. Marshall,Timothy A. Daugird,Sidney L. Lisanza,María José Sandí,Mitsu Ikura,Mitsu Ikura,John Sondek,Robert Rottapel,Robert Rottapel,Klaus M. Hahn,Gaudenz Danuser +14 more
TL;DR: Fluorescent biosensors reveal the synergistic role of microtubule dynamics and Src phosphorylation in regulating GEF-H1 activity locally during cell migration.
Journal ArticleDOI
The regulation of RhoA at focal adhesions by StarD13 is important for astrocytoma cell motility.
Bassem D. Khalil,Samer Hanna,Bechara A. Saykali,Sally El-Sitt,Anita Nasrallah,Daniel J. Marston,Marwan El-Sabban,Klaus M. Hahn,Marc Symons,Mirvat El-Sibai +9 more
TL;DR: The knock down of StarD13, a GTPase activating protein for RhoA and Cdc42, inhibits astrocytoma cell migration through modulating focal adhesion dynamics and cell adhesion.
Journal ArticleDOI
Simple one-pot preparation of water-soluble, cysteine-reactive cyanine and merocyanine dyes for biological imaging.
TL;DR: A simple one-pot-procedure for preparation of protein-reactive, water-soluble merocyanine and cyanine dyes has been developed and iodo- and chloroacetamido derivatives were shown to be useful in protein labeling.