K
Klaus M. Hahn
Researcher at University of North Carolina at Chapel Hill
Publications - 215
Citations - 16976
Klaus M. Hahn is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: RHOA & Proto-oncogene tyrosine-protein kinase Src. The author has an hindex of 61, co-authored 210 publications receiving 15343 citations. Previous affiliations of Klaus M. Hahn include University of California, Berkeley & University of California, San Diego.
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Journal ArticleDOI
Biosensors for Characterizing the Dynamics of Rho Family GTPases in Living Cells
TL;DR: Detailed protocols for the application of three biosensors exemplifying different designs are described—first, a design in which an environmentally sensitive dye is used to report the activation of endogenous Cdc42, followed by two biosensor based on FRET, one using intramolecular and the other intermolecular FRET.
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CellGeo: A computational platform for the analysis of shape changes in cells with complex geometries
Denis Tsygankov,Colleen G. Bilancia,Eric A. Vitriol,Klaus M. Hahn,Mark Peifer,Timothy C. Elston +5 more
TL;DR: The open source MATLAB application CellGeo is a user-friendly computational platform that allows simultaneous, automated tracking and analysis of dynamic changes in cell shape, including protrusions ranging from filopodia to lamellipodiato growth cones.
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The δ subunit of AP-3 is required for efficient transport of VSV-G from the trans-Golgi network to the cell surface
TL;DR: It is demonstrated that a single sorting sequence can interact with sequential coat machineries to direct transport through the secretory pathway and use of this compact sorting domain reflects a need for both efficient endoplasmic reticulum export and concentration of VSV-G into specialized post-trans-Golgi network secretory-lysosome type transport containers.
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RhoA/ROCK-mediated switching between Cdc42- and Rac1-dependent protrusion in MTLn3 carcinoma cells
Mirvat El-Sibai,Olivier Pertz,Huan Pang,Shu Chin Yip,Mike Lorenz,Marc Symons,Marc Symons,John S. Condeelis,Klaus M. Hahn,Jonathan M. Backer +9 more
TL;DR: A novel role for Rho in coordinating signaling by Rac and Cdc42 is described, which causes a switch between CDC42 and Rac-1 as the dominant Rho GTPase driving protrusion in carcinoma cells.
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Control of Protein Activity and Cell Fate Specification via Light-Mediated Nuclear Translocation.
Hayretin Yumerefendi,Daniel J. Dickinson,Hui Wang,Seth P. Zimmerman,James E. Bear,Bob Goldstein,Klaus M. Hahn,Brian Kuhlman +7 more
TL;DR: It is shown that the switch, referred to as LANS (light-activated nuclear shuttle), functions in the C. elegans embryo and allows for control of nuclear localization in individual cells and can be a valuable experimental method for spatial and temporal control ofnuclear localization in vivo.