K
Klavs R. Hansen
Researcher at University of Copenhagen
Publications - 5
Citations - 820
Klavs R. Hansen is an academic researcher from University of Copenhagen. The author has contributed to research in topics: Schizosaccharomyces & Schizosaccharomyces pombe. The author has an hindex of 5, co-authored 5 publications receiving 762 citations. Previous affiliations of Klavs R. Hansen include Cold Spring Harbor Laboratory.
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Journal ArticleDOI
Comparative functional genomics of the fission yeasts
Nicholas Rhind,Zehua Chen,Moran Yassour,Moran Yassour,Dawn Thompson,Brian J. Haas,Naomi Habib,Ilan Wapinski,Ilan Wapinski,Sushmita Roy,Michael F. Lin,David I. Heiman,Sarah Young,Kanji Furuya,Yabin Guo,Alison L. Pidoux,Huei Mei Chen,Barbara Robbertse,Jonathan M. Goldberg,Keita Aoki,Elizabeth H. Bayne,Aaron M. Berlin,Christopher A. Desjardins,Edward Dobbs,Livio Dukaj,Lin Fan,Michael Fitzgerald,Courtney French,Sharvari Gujja,Klavs R. Hansen,Daniel Keifenheim,Joshua Z. Levin,Rebecca A. Mosher,Carolin A. Müller,Jenna Pfiffner,Margaret Priest,Carsten Russ,Agata Smialowska,Agata Smialowska,Peter Swoboda,Sean M. Sykes,Matthew W. Vaughn,Sonya Vengrova,Ryan J. Yoder,Qiandong Zeng,Robin C. Allshire,David C. Baulcombe,Bruce W. Birren,William Brown,Karl Ekwall,Karl Ekwall,Manolis Kellis,Janet Leatherwood,Henry L. Levin,Hanah Margalit,Robert A. Martienssen,Conrad A. Nieduszynski,Joseph W. Spatafora,Nir Friedman,Jacob Z. Dalgaard,Peter Baumann,Peter Baumann,Peter Baumann,Hironori Niki,Aviv Regev,Aviv Regev,Chad Nusbaum +66 more
TL;DR: Differences in gene content and regulation explain why, unlike the budding yeast of Saccharomycotina, fission yeasts cannot use ethanol as a primary carbon source and provide tools for investigation across the Schizosaccharomyces clade.
Journal ArticleDOI
Global Effects on Gene Expression in Fission Yeast by Silencing and RNA Interference Machineries
Klavs R. Hansen,Gavin Burns,Juan Mata,Tom Volpe,Robert A. Martienssen,Jürg Bähler,Geneviève Thon +6 more
TL;DR: It is indicated that the RNAi and Clr proteins show only a limited functional overlap and that the ClR proteins play more global roles in gene silencing, while the wtf family of repeated sequences seems to be repressed by histone deacetylation independent of RNAi.
Journal ArticleDOI
The Clr7 and Clr8 Directionality Factors and the Pcu4 Cullin Mediate Heterochromatin Formation in the Fission Yeast Schizosaccharomyces pombe
Geneviève Thon,Klavs R. Hansen,Susagna Padrissa Altes,Deepak Sidhu,Gurjeet Singh,Janne Verhein-Hansen,Michael J. Bonaduce,Amar J. S. Klar +7 more
TL;DR: A genetic screen for directionality mutants revealed the essential role of two previously uncharacterized factors, Clr7 and Clr8, in heterochromatin formation and suggested a role for ubiquitination at this early stage prior to the action of the Clr4 histone methyl-transferase.
Journal ArticleDOI
Evolutionary-conserved telomere-linked helicase genes of fission yeast are repressed by silencing factors, RNAi components and the telomere-binding protein Taz1
TL;DR: It is found that mutants lacking the histone methyltransferase Clr4, the Pcu4 cullin, Clr7 or Clr8, accumulate high levels of tlh forward and reverse transcripts, demonstrating that the tlH genes are normally repressed by heterochromatin.
Journal ArticleDOI
H3K9me-independent gene silencing in fission yeast heterochromatin by Clr5 and histone deacetylases.
Klavs R. Hansen,Idit Hazan,Sreenath Shanker,Stephen Watt,Janne Verhein-Hansen,Jürg Bähler,Robert A. Martienssen,Janet F. Partridge,Amikam Cohen,Geneviève Thon +9 more
TL;DR: It is found that Clr5 controls gene expression at multiple chromosomal locations in addition to affecting the mating-type region, and like the multi-functional Atf1 transcription factor, controls sexual differentiation and genome integrity at several levels.