K
Korinna Straube
Researcher at Yale University
Publications - 13
Citations - 647
Korinna Straube is an academic researcher from Yale University. The author has contributed to research in topics: RNA splicing & RNA. The author has an hindex of 6, co-authored 12 publications receiving 495 citations. Previous affiliations of Korinna Straube include Max Planck Society.
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Journal ArticleDOI
Splicing of Nascent RNA Coincides with Intron Exit from RNA Polymerase II.
Fernando Carrillo Oesterreich,Lydia Herzel,Lydia Herzel,Korinna Straube,Katja Hujer,Jonathon Howard,Karla M. Neugebauer +6 more
TL;DR: Two single-molecule nascent RNA sequencing methods are presented that directly determine the progress of splicing catalysis as a function of Pol II position and it is proposed that matched rates streamline the gene expression pathway, while allowing regulation through kinetic competition.
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First Exon Length Controls Active Chromatin Signatures and Transcription
TL;DR: First exon length is predictive for gene activity and determines transcription quantity and quality as well as chromatin signatures, and splicing inhibition and intron deletion reduce H3K4me3 levels and transcriptional output.
Journal ArticleDOI
Long-read sequencing of nascent RNA reveals coupling among RNA processing events
TL;DR: Overall splicing of individual nascent transcripts, 3' end formation, and mRNA half-life depend on the splicing status of neighboring introns, suggesting crosstalk among spliceosomes and the polyA cleavage machinery during transcription elongation.
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The Coilin Interactome Identifies Hundreds of Small Noncoding RNAs that Traffic through Cajal Bodies
Martin Machyna,Stephanie Kehr,Korinna Straube,Korinna Straube,Dennis Kappei,Frank Buchholz,Falk Butter,Jernej Ule,Jana Hertel,Peter F. Stadler,Karla M. Neugebauer,Karla M. Neugebauer +11 more
TL;DR: Coilin protein scaffolds Cajal bodies (CBs) -subnuclear compartments enriched in small nuclear RNAs (snRNAs)-and promotes efficient spliceosomal snRNP assembly and makes CBs the cellular hub of small ncRNA metabolism.
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Dynamic RNA-protein interactions underlie the zebrafish maternal-to-zygotic transition.
Vladimir Despic,Mario Dejung,Mengting Gu,Jayanth Krishnan,Jing Zhang,Lydia Herzel,Korinna Straube,Mark Gerstein,Falk Butter,Karla M. Neugebauer +9 more
TL;DR: This study identifies global changes in RNA-protein interactions during vertebrate MZT and shows that Hnrnpa1 RNA-binding activities are spatially and temporally coordinated to regulate RNA metabolism during early development.