D
Dennis Kappei
Researcher at National University of Singapore
Publications - 54
Citations - 1756
Dennis Kappei is an academic researcher from National University of Singapore. The author has contributed to research in topics: Gene & Biology. The author has an hindex of 17, co-authored 41 publications receiving 1225 citations. Previous affiliations of Dennis Kappei include Curie Institute & Max Planck Society.
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Journal ArticleDOI
Ageing and the telomere connection: An intimate relationship with inflammation.
Jingwen Zhang,Grishma Rane,Xiaoyun Dai,Muthu K. Shanmugam,Frank Arfuso,Ramar Perumal Samy,Mitchell K.P. Lai,Dennis Kappei,Alan Prem Kumar,Gautam Sethi +9 more
TL;DR: The intricate association between the various inflammatory molecules and telomeres that together contribute to the ageing process and related diseases are summarized.
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Four different subunits are essential for expressing the synaptic glutamate receptor at neuromuscular junctions of Drosophila.
Gang Qin,Tobias J. Schwarz,Robert J. Kittel,Andreas Schmid,Tobias M. Rasse,Dennis Kappei,Evgeni Ponimaskin,Manfred Heckmann,Stephan J. Sigrist +8 more
TL;DR: This study identifies a fourth and a fifth subunit expressed in the neuromuscular system of Drosophila, which are required for the synaptic expression of all other glutamate receptor subunits and open the way for a further characterization of in vivo glutamate receptor assembly and trafficking.
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The developmental proteome of Drosophila melanogaster .
Nuria Casas-Vila,Alina Bluhm,Sergi Sayols,Nadja Dinges,Mario Dejung,Tina Altenhein,Dennis Kappei,Benjamin Altenhein,Benjamin Altenhein,Jean-Yves Roignant,Falk Butter +10 more
TL;DR: This work applies label-free quantitative proteomics to explore proteome remodeling across Drosophila's life cycle, resulting in 7952 proteins, and provides a high temporal-resolved embryogenesis proteome of 5458 proteins.
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The Coilin Interactome Identifies Hundreds of Small Noncoding RNAs that Traffic through Cajal Bodies
Martin Machyna,Stephanie Kehr,Korinna Straube,Korinna Straube,Dennis Kappei,Frank Buchholz,Falk Butter,Jernej Ule,Jana Hertel,Peter F. Stadler,Karla M. Neugebauer,Karla M. Neugebauer +11 more
TL;DR: Coilin protein scaffolds Cajal bodies (CBs) -subnuclear compartments enriched in small nuclear RNAs (snRNAs)-and promotes efficient spliceosomal snRNP assembly and makes CBs the cellular hub of small ncRNA metabolism.
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Targetable BET proteins- and E2F1-dependent transcriptional program maintains the malignancy of glioblastoma
Liang Xu,Ye Chen,Anand Mayakonda,Lynnette Koh,Yuk Kien Chong,Dennis L. Buckley,Edwin Sandanaraj,See Wee Lim,Ruby Yu-Tong Lin,Xin-Yu Ke,Moli Huang,Moli Huang,Jianxiang Chen,Wendi Sun,Lingzhi Wang,Boon Cher Goh,Huy Q. Dinh,Dennis Kappei,Georg E. Winter,Ling-Wen Ding,Beng Ti Ang,Benjamin P. Berman,James E. Bradner,Carol Tang,H. Phillip Koeffler,H. Phillip Koeffler +25 more
TL;DR: dBET6-induced degradation of BET proteins exerts superior antiproliferation effects compared to conventional B BIs and overcomes both intrinsic and acquired resistance to BBIs in GBM cells.