Kouichi Hashimoto

TL;DR: An infusion as PEGylated liposomes augmented the cardioprotective effects of adenosine against ischemia/reperfusion injury and reduced its unfavorable hemodynamic effects.

TL;DR: It would be expected that DXR-SIL[anti-MT1-MMP(Fab')] may achieve direct tumor cell killing and indirect tumor cell kill via the destruction of the tumor endothelium in vivo, and this strategy may have the potential for overcoming some major limitations in conventional chemotherapy in vivo.

TL;DR: The reliable evaluation method for siRNA delivery in vitro was established by using NFAT reporter HeLa stable cell line or CHO (pMAM-luc) cell line that had DNA encoding luciferase, and it was considered that the cotransfection method should be avoided when the authors confirm RNAi efficiency.

TL;DR: In this article, the authors presented a composition with weak cytotoxicity for introducing a nucleic acid, such as a short oligonucleotide or a gene, into a cell and expression of the gene in the cell with improved capability for introduction of the nucleic acids, and a novel compound contained in the composition.

TL;DR: In this paper, a composition for the intracellular introduction of a nucleic acid was proposed, which was improved by using a compound represented by the following formula: (I) (wherein R1 and R2 are the same or different and each means a C12-22 (un)saturated hydrocarbon group; R3 means C1-6 alkyl or C 1-6 hydroxyalkyl; m means an integer of 1-10; and X means halogeno) and a phospholipid.