Kousick Biswas

TL;DR: Interventions targeting five pathogens can substantially reduce the burden of moderate-to-severe diarrhoea and suggest new methods and accelerated implementation of existing interventions (rotavirus vaccine and zinc) are needed to prevent disease and improve outcomes.

TL;DR: The clinical and epidemiological methods used to conduct the Global Enteric Multicenter Study (GEMS), a 3-year, prospective, age-stratified, case/control study to estimate the population-based burden, microbiologic etiology, and adverse clinical consequences of acute moderate-to-severe diarrhea among a censused population of children seeking care at health centers in sub-Saharan Africa and South Asia, are described.

TL;DR: A quadrivalent vaccine that includes O antigens from S. sonnei, S. flexneri, and S.flexneri 6 should provide broad protection in Shigella case isolates.

TL;DR: Weighted adjusted population attributable fractions showed that most attributable cases of MSD and LSD were due to rotavirus, Cryptosporidium spp, enterotoxigenic Escherichia coli encoding heat-stable toxin, and Shigella spp.

TL;DR: There was no evidence of difference in remission rates between the active and sham treatments and the findings may reflect the importance of close clinical surveillance, rigorous monitoring of concomitant medication, and regular interaction with clinic staff in bringing about significant improvement in this treatment-resistant population.