Kristin R. Swanson

TL;DR: A new method to converge on parameter sets that fit an agent-based model to multiscale data using a model of glioblastoma as an example is detailed.

TL;DR: The finding that less diffusely invasive tumors are associated with greater volumetric response to TMZ suggests patients with these tumors may benefit from additional adjuvant TMZ cycles, even for those without MGMT methylation.

TL;DR: Anatomical boundaries to tumor growth measurably deflect progression and affect estimates of kinetic parameters when those data are in a linear regime, which reliably updates kinetic parameters to fit anatomic computational models to clinically derived subject data.

TL;DR: Using a quantitative imaging-based measure of response, this work found that temozolomide chemotherapy is more effective in female compared to male GBM patients, and identified novel sex-specific molecular subtypes of GBM in which cell cycle and integrin signaling were identified as the critical determinants of survival for male and female patients, respectively.

TL;DR: The evidence for DC, nuances regarding patient selection, and applicability of DC for supratentorial intracerebral hemorrhage and posterior fossa ischemic and hemorrhagic stroke are explored.