K
Kristina Hettne
Researcher at Leiden University Medical Center
Publications - 67
Citations - 1636
Kristina Hettne is an academic researcher from Leiden University Medical Center. The author has contributed to research in topics: Workflow & Metadata. The author has an hindex of 21, co-authored 64 publications receiving 1306 citations. Previous affiliations of Kristina Hettne include Leiden University & Maastricht University.
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Journal ArticleDOI
Recognition of chemical entities: combining dictionary-based and grammar-based approaches.
TL;DR: An ensemble system that combines dictionary-based and grammar-based approaches for chemical named entity recognition, outperforming any of the individual systems that were considered, is developed.
Proceedings Article
Best practices for workflow design: how to prevent workflow decay
Kristina Hettne,Katy Wolstencroft,Khalid Belhajjame,Carole Goble,Eleni Mina,Harish Dharuri,Lourdes Verdes-Montenegro,Julián Garrido,David De Roure,Marco Roos +9 more
TL;DR: It is argued that good workflow design is a prerequisite for repairing a workflow, or redesigning an equivalent workflow pattern with new components, and the semantic tooling that is being developed in the Workflow4Ever project to support these best practices are presented.
Journal ArticleDOI
Structuring research methods and data with the research object model: genomics workflows as a case study
Kristina Hettne,Harish Dharuri,Jun Zhao,Katherine Wolstencroft,Katherine Wolstencroft,Khalid Belhajjame,Stian Soiland-Reyes,Eleni Mina,Mark Thompson,Don Cruickshank,Lourdes Verdes-Montenegro,Julián Garrido,David De Roure,Oscar Corcho,Graham Klyne,Reinout van Schouwen,Peter A C 't Hoen,Sean Bechhofer,Carole Goble,Marco Roos +19 more
TL;DR: In this paper, a workflow-centric Research Object (RO) model is proposed to aggregate and annotate the resources used in a bioinformatics experiment, allowing to retrieve the conclusions of the experiment in the context of the driving hypothesis, the executed workflows and their input data.
Journal ArticleDOI
Structuring research methods and data with the Research Object model: genomics workflows as a case study
Kristina Hettne,Harish Dharuri,Jun Zhao,Katherine Wolstencroft,Katherine Wolstencroft,Khalid Belhajjame,Stian Soiland-Reyes,Eleni Mina,Mark Thompson,Don Cruickshank,Lourdes Verdes-Montenegro,Julián Garrido,David De Roure,Oscar Corcho,Graham Klyne,Reinout van Schouwen,Peter A C 't Hoen,Sean Bechhofer,Carole Goble,Marco Roos +19 more
TL;DR: Applying a workflow-centric RO model to aggregate and annotate the resources used in a bioinformatics experiment allowed us to retrieve the conclusions of the experiment in the context of the driving hypothesis, the executed workflows and their input data.
Journal ArticleDOI
Common disease signatures from gene expression analysis in Huntington's disease human blood and brain.
Eleni Mina,Willeke M. C. van Roon-Mom,Kristina Hettne,Erik W. van Zwet,Jelle J. Goeman,Christian Neri,Peter A C 't Hoen,Barend Mons,Marco Roos +8 more
TL;DR: It is demonstrated that HD blood exhibits dysregulation that is similar to brain at a functional level, but not necessarily at the level of individual genes.