K
Kun Yang
Researcher at University of Michigan
Publications - 21
Citations - 2195
Kun Yang is an academic researcher from University of Michigan. The author has contributed to research in topics: Cancer & Ovarian cancer. The author has an hindex of 11, co-authored 17 publications receiving 1961 citations.
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Journal ArticleDOI
Complementary signaling pathways regulate the unfolded protein response and are required for C. elegans development
Xiaohua Shen,Ronald E. Ellis,Kyungho Lee,Chuan Yin Liu,Kun Yang,Aaron Solomon,Hiderou Yoshida,Richard I. Morimoto,David M. Kurnit,Kazutoshi Mori,Randal J. Kaufman +10 more
TL;DR: It is proposed that UPR transcriptional activation by ire-1 as well as translational attenuation by pek-1 maintain ER homeostasis, and the results demonstrate that the UPR and ERHomeostasis are essential for metazoan development.
Journal ArticleDOI
EGFR, p16, HPV Titer, Bcl-xL and p53, Sex, and Smoking As Indicators of Response to Therapy and Survival in Oropharyngeal Cancer
Bhavna Kumar,Kitrina G. Cordell,Julia S. Lee,Francis P. Worden,Mark E. Prince,Huong H. Tran,Gregory T. Wolf,Susan G. Urba,Douglas B. Chepeha,Theodoros N. Teknos,Avraham Eisbruch,Christina Tsien,Jeremy M. G. Taylor,Nisha J. D'Silva,Kun Yang,David M. Kurnit,Joshua A. Bauer,Carol R. Bradford,Thomas E. Carey +18 more
TL;DR: Low EGFR and high p16 (or higher HPV titer) expression are markers of good response to organ-sparing therapy and outcome, whereas high EGFR expression, combined low p53/high Bcl-xL expression, female sex, and smoking are associated with a poor outcome.
Journal ArticleDOI
Chemoselection As a Strategy for Organ Preservation in Advanced Oropharynx Cancer: Response and Survival Positively Associated With HPV16 Copy Number
Francis P. Worden,Bhavna Kumar,Julia S. Lee,Gregory T. Wolf,Kitrina G. Cordell,Jeremy M. G. Taylor,Susan G. Urba,Avraham Eisbruch,Theodoros N. Teknos,Douglas B. Chepeha,Mark E. Prince,Christina Tsien,Nisha J. D'Silva,Kun Yang,David M. Kurnit,Heidi L. Mason,Tamara H. Miller,Nancy E. Wallace,Carol R. Bradford,Thomas E. Carey +19 more
TL;DR: Although the numbers in this study are small, IC followed by CRT is an effective treatment for SCCOP, especially in patients with HPV-positive tumors; however, for patients who do not respond to treatment, alternative treatments must be developed.
Journal ArticleDOI
Response to therapy and outcomes in oropharyngeal cancer are associated with biomarkers including human papillomavirus, epidermal growth factor receptor, gender, and smoking.
Bhavna Kumar,Kitrina G. Cordell,Julia S. Lee,Mark E. Prince,Huong H. Tran,Gregory T. Wolf,Susan G. Urba,Francis P. Worden,Douglas B. Chepeha,Theodoros N. Teknos,Avraham Eisbruch,Christina Tsien,Jeremy M. G. Taylor,Nisha J. D'Silva,Kun Yang,David M. Kurnit,Carol R. Bradford,Thomas E. Carey +17 more
TL;DR: The presence and titer of high risk human papilloma virus and expression of epidermal growth factor receptor in pre-treatment biopsies, as well as smoking and gender were examined in oropharynx cancer patients enrolled in an organ sparing trial.
Journal ArticleDOI
A Pan-ALDH1A Inhibitor Induces Necroptosis in Ovarian Cancer Stem-like Cells.
Ilana Chefetz,Edward Grimley,Kun Yang,Linda Hong,Ekaterina V. Vinogradova,Radu M. Suciu,Ilya Kovalenko,David Karnak,Cynthia A. Morgan,Mikhail Chtcherbinine,Cameron D. Buchman,Brandt C. Huddle,Scott J. Barraza,Meredith A. Morgan,Kara A. Bernstein,Euisik Yoon,David B. Lombard,Andrea H. Bild,Geeta Mehta,Iris L. Romero,Chun-Yi Chiang,Charles N. Landen,Benjamin F. Cravatt,Thomas D. Hurley,Scott D. Larsen,Ronald J. Buckanovich +25 more
TL;DR: Two AL DH1A family selective inhibitors are identified and link ALDH1A with necroptosis and confirm the family as a critical therapeutic target to overcome chemotherapy resistance and improve patient outcomes.