K
Kung-Chi Chang
Researcher at Cold Spring Harbor Laboratory
Publications - 14
Citations - 851
Kung-Chi Chang is an academic researcher from Cold Spring Harbor Laboratory. The author has contributed to research in topics: Cancer & Mammary tumor. The author has an hindex of 6, co-authored 14 publications receiving 585 citations. Previous affiliations of Kung-Chi Chang include Stony Brook University & National Yang-Ming University.
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Journal ArticleDOI
Differentiation of mammary tumors and reduction in metastasis upon Malat1 lncRNA loss
Gayatri Arun,Sarah D. Diermeier,Martin Akerman,Kung-Chi Chang,Kung-Chi Chang,J. Erby Wilkinson,Stephen Hearn,Youngsoo Kim,A. Robert MacLeod,Adrian R. Krainer,Adrian R. Krainer,Larry Norton,Edi Brogi,Mikala Egeblad,David L. Spector,David L. Spector +15 more
TL;DR: It is reported that genetic loss or systemic knockdown of Malat1 using antisense oligonucleotides (ASOs) in the MMTV-PyMT- and Her2/neu-amplified tumor organoids model results in slower tumor growth accompanied by significant differentiation into cystic tumors and a reduction in metastasis.
Journal ArticleDOI
CIP2A is a target of bortezomib in human triple negative breast cancer cells
Ling Ming Tseng,Chunyu Liu,Chunyu Liu,Kung-Chi Chang,Kung-Chi Chang,Pei-Yi Chu,Chung Wai Shiau,Kuen-Feng Chen +7 more
TL;DR: CIP2A is a major determinant mediating bortezomib-induced apoptosis in TNBC cells and may be a potential therapeutic target in T NBC, which currently has no specific therapeutic targets.
Proceedings ArticleDOI
Abstract PR11: Differentiation of mammary tumors and reduction in metastasis upon Malat1 LncRNA loss
Gayatri Arun,Sarah D. Diermeier,Martin Akerman,Kung-Chi Chang,J. Erby Wilkinson,Stephen Hearn,Youngsoo Kim,A. Robert MacLeod,Adrian R. Krainer,Larry Norton,Edi Brogi,Mikala Egeblad,David L. Spector +12 more
TL;DR: RNA-FISH experiments on primary tumor and metastatic nodules from patients with luminal type breast cancer revealed that MALAT1 lncRNA is 4-5 times up regulated in metastatic nodsules compared to primary tumors, which strongly suggests that Malat1 plays an important role in the metastatic progression of luminal breast cancers.
Journal ArticleDOI
Novel sorafenib analogues induce apoptosis through SHP-1 dependent STAT3 inactivation in human breast cancer cells
Chunyu Liu,Ling Ming Tseng,Ling Ming Tseng,Jung Chen Su,Kung-Chi Chang,Kung-Chi Chang,Pei-Yi Chu,Wei Tien Tai,Chung Wai Shiau,Kuen-Feng Chen +9 more
TL;DR: Novel sorafenib analogues SC-1 and SC-43 induce apoptosis through SHP-1 dependent STAT3 inactivation and demonstrate greater potency than sorafinib in human breast cancer cells.
Journal ArticleDOI
MaTAR25 lncRNA regulates the Tensin1 gene to impact breast cancer progression.
Kung-Chi Chang,Kung-Chi Chang,Sarah D. Diermeier,Sarah D. Diermeier,Allen T. Yu,Allen T. Yu,Lily D. Brine,Suzanne Russo,Sonam Bhatia,Habeeb Alsudani,Karen Kostroff,Tawfiqul Bhuiya,Edi Brogi,Darryl J. Pappin,C. Frank Bennett,Frank Rigo,David L. Spector,David L. Spector +17 more
TL;DR: MaTAR25 as mentioned in this paper is a nuclear enriched and chromatin associated lncRNA that plays a role in mammary tumor cell proliferation, migration, and invasion, both in vitro and in vivo.