M
Martin Akerman
Researcher at Cold Spring Harbor Laboratory
Publications - 31
Citations - 2307
Martin Akerman is an academic researcher from Cold Spring Harbor Laboratory. The author has contributed to research in topics: RNA splicing & Alternative splicing. The author has an hindex of 19, co-authored 26 publications receiving 1859 citations. Previous affiliations of Martin Akerman include Sheba Medical Center & Technion – Israel Institute of Technology.
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Journal ArticleDOI
Differentiation of mammary tumors and reduction in metastasis upon Malat1 lncRNA loss
Gayatri Arun,Sarah D. Diermeier,Martin Akerman,Kung-Chi Chang,Kung-Chi Chang,J. Erby Wilkinson,Stephen Hearn,Youngsoo Kim,A. Robert MacLeod,Adrian R. Krainer,Adrian R. Krainer,Larry Norton,Edi Brogi,Mikala Egeblad,David L. Spector,David L. Spector +15 more
TL;DR: It is reported that genetic loss or systemic knockdown of Malat1 using antisense oligonucleotides (ASOs) in the MMTV-PyMT- and Her2/neu-amplified tumor organoids model results in slower tumor growth accompanied by significant differentiation into cystic tumors and a reduction in metastasis.
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The splicing factor SRSF1 regulates apoptosis and proliferation to promote mammary epithelial cell transformation
Olga Anczuków,Avi Z. Rosenberg,Avi Z. Rosenberg,Martin Akerman,Shipra Das,Shipra Das,Lixing Zhan,Lixing Zhan,Rotem Karni,Rotem Karni,Senthil K. Muthuswamy,Senthil K. Muthuswamy,Adrian R. Krainer +12 more
TL;DR: SRSF 1 can promote breast cancer, and SRSF1 itself or its downstream effectors may be valuable targets for the development of therapeutics.
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SRSF1-Regulated Alternative Splicing in Breast Cancer.
Olga Anczuków,Martin Akerman,Antoine Cléry,Jie Wu,Chen Shen,Nitin H. Shirole,Amanda C. Raimer,Shuying Sun,Mads A. Jensen,Yimin Hua,Frédéric H.-T. Allain,Adrian R. Krainer +11 more
TL;DR: SRSF1 positive and negative regulatory mechanisms, and oncogenic AS events that represent potential targets for therapeutics development are uncovered.
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Oncogenic Splicing Factor SRSF1 Is a Critical Transcriptional Target of MYC
TL;DR: It is shown that SRSF1 is a direct target of the transcription factor oncoprotein MYC, a critical MYC target that contributes to its oncogenic potential by enabling MYC to regulate the expression of specific protein isoforms through alternative splicing.
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SFmap: a web server for motif analysis and prediction of splicing factor binding sites
TL;DR: SFmap is a web server for predicting putative SF binding sites in genomic data that implements the COS(WR) algorithm, which computes similarity scores for a given regulatory motif based on information derived from its sequence environment and its evolutionary conservation.