S
Stephen Hearn
Researcher at Cold Spring Harbor Laboratory
Publications - 33
Citations - 10753
Stephen Hearn is an academic researcher from Cold Spring Harbor Laboratory. The author has contributed to research in topics: Neurodegeneration & Gene silencing. The author has an hindex of 25, co-authored 33 publications receiving 9010 citations. Previous affiliations of Stephen Hearn include University of Western Ontario & Hospital for Sick Children.
Papers
More filters
Journal ArticleDOI
Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence.
Masashi Narita,Sabrina Nuñez,Sabrina Nuñez,Edith Heard,Masako Narita,Athena W. Lin,Stephen Hearn,David L. Spector,Gregory J. Hannon,Scott W. Lowe +9 more
TL;DR: A distinct heterochromatic structure that accumulates in senescent human fibroblasts is described, which is designated senescence-associated heterochROMatic foci (SAHF) and is associated with the stable repression of E2F target genes.
Journal ArticleDOI
Senescence of activated stellate cells limits liver fibrosis
Valery Krizhanovsky,Monica Yon,Monica Yon,Ross A. Dickins,Stephen Hearn,Janelle Simon,Janelle Simon,Cornelius Miething,Herman T. Yee,Lars Zender,Scott W. Lowe,Scott W. Lowe +11 more
TL;DR: In this paper, the authors show that senescent cells accumulate in murine livers treated to produce fibrosis, a precursor pathology to cirrhosis, derived primarily from activated hepatic stellate cells, which initially proliferate in response to liver damage and produce the extracellular matrix.
Journal ArticleDOI
Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer
Daniel Öhlund,Daniel Öhlund,Daniel Öhlund,Abram Handly-Santana,Abram Handly-Santana,Giulia Biffi,Giulia Biffi,Ela Elyada,Ela Elyada,Ana S. Almeida,Ana S. Almeida,Mariano Ponz-Sarvise,Mariano Ponz-Sarvise,Mariano Ponz-Sarvise,Vincenzo Corbo,Tobiloba E. Oni,Tobiloba E. Oni,Tobiloba E. Oni,Stephen Hearn,Eun Jung Lee,Eun Jung Lee,Iok In Christine Chio,Iok In Christine Chio,Chang-Il Hwang,Chang-Il Hwang,Hervé Tiriac,Hervé Tiriac,Lindsey A. Baker,Lindsey A. Baker,Dannielle D. Engle,Dannielle D. Engle,Christine Feig,Anne Kultti,Mikala Egeblad,Douglas T. Fearon,James M. Crawford,Hans Clevers,Young-Kyu Park,Young-Kyu Park,David A. Tuveson,David A. Tuveson +40 more
TL;DR: Direct evidence for CAF heterogeneity in PDA tumor biology is provided, providing direct evidence for disease etiology and therapeutic development in mouse and human PDA tissue.
Journal Article
Senescence of Activated Stellate Cells Limits Liver Fibrosis
Valery Krizhanovsky,Monica Yon,Monica Yon,Ross A. Dickins,Stephen Hearn,Janelle Simon,Janelle Simon,Cornelius Miething,Herman T. Yee,Lars Zender,Scott W. Lowe,Scott W. Lowe +11 more
TL;DR: It is shown that senescent cells accumulate in murine livers treated to produce fibrosis, a precursor pathology to cirrhosis, and natural killer cells preferentially kill senescent activated stellate cells in vitro and in vivo, thereby facilitating the resolution of fibrosis.
Journal ArticleDOI
Regulating Gene Expression through RNA Nuclear Retention
Kannanganattu V. Prasanth,Supriya G. Prasanth,Zhenyu Xuan,Stephen Hearn,Susan M. Freier,C. Frank Bennett,Michael Q. Zhang,David L. Spector +7 more
TL;DR: A role of the cell nucleus in harboring RNA molecules that are not immediately needed to produce proteins but whose cytoplasmic presence is rapidly required upon physiologic stress is revealed.