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Kutty Selva Nandakumar
Researcher at Southern Medical University
Publications - 119
Citations - 4653
Kutty Selva Nandakumar is an academic researcher from Southern Medical University. The author has contributed to research in topics: Arthritis & Antibody. The author has an hindex of 33, co-authored 113 publications receiving 3851 citations. Previous affiliations of Kutty Selva Nandakumar include Madurai Kamaraj University & Karolinska Institutet.
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Journal ArticleDOI
Collagen type II-specific monoclonal antibody-induced arthritis in mice: description of the disease and the influence of age, sex, and genes.
TL;DR: It is concluded that CAIA is an acute arthritis triggered by antibody binding and neutrophils bypassing immune activation but with many characteristics in common with collagen-induced arthritis.
Journal ArticleDOI
Structure and pathogenicity of antibodies specific for citrullinated collagen type II in experimental arthritis.
Hüseyin Uysal,Robert Bockermann,Kutty Selva Nandakumar,Kutty Selva Nandakumar,Bettina Sehnert,Estelle Bajtner,Åke Engström,Guy Serre,Harald Burkhardt,Marjolein M. G. M. Thunnissen,Rikard Holmdahl,Rikard Holmdahl +11 more
TL;DR: It is proposed that autoimmunity to CII, leading to the production of antibodies specific for both native and citrullinated CII is an important pathogenic factor in the development of RA.
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Regulation of autoantibody activity by the IL-23-T H 17 axis determines the onset of autoimmune disease.
R Pfeifle,Tobias Rothe,Natacha Ipseiz,Hans Scherer,Stephan Culemann,Ulrike Harre,Jochen A. Ackermann,Martina Seefried,Arnd Kleyer,Stefan Uderhardt,Benjamin Haugg,Axel J. Hueber,Patrick Daum,Gordon F. Heidkamp,Changrong Ge,Sybille Böhm,Anja Lux,Wolfgang Schuh,Iryna Magorivska,Kutty Selva Nandakumar,Erik Lönnblom,Christoph Becker,Diana Dudziak,Manfred Wuhrer,Yoann Rombouts,Yoann Rombouts,Yoann Rombouts,Carolien A. M. Koeleman,René E. M. Toes,Thomas Winkler,Rikard Holmdahl,Martin Herrmann,Stephan Blüml,Falk Nimmerjahn,Georg Schett,Gerhard Krönke +35 more
TL;DR: An IL-23–TH17 cell–dependent pathway is identified that controls autoantibody activity and unmasks a preexisting breach in immunotolerance in rheumatoid arthritis.
Journal ArticleDOI
Macrophages suppress T cell responses and arthritis development in mice by producing reactive oxygen species
Kyra A. Gelderman,Malin Hultqvist,Angela Pizzolla,Ming Zhao,Kutty Selva Nandakumar,Ragnar Mattsson,Rikard Holmdahl +6 more
TL;DR: Macrophage-derived ROS play a role in T cell selection, maturation, and differentiation, and also a suppressive role inT cell activation, and thereby mediate protection against autoimmune diseases like arthritis.
Journal ArticleDOI
Epitope-specific recognition of type II collagen by rheumatoid arthritis antibodies is shared with recognition by antibodies that are arthritogenic in collagen-induced arthritis in the mouse.
Harald Burkhardt,Tobias Koller,Åke Engström,Kutty Selva Nandakumar,Javier Turnay,Hans G. Kraetsch,Joachim R. Kalden,Rikard Holmdahl +7 more
TL;DR: In RA, in contrast to degenerative joint disease, RP, and SLE, autoantibody responses are directed to an evolutionary conserved CII structure that is also targeted by pathogenic autoimmune responses in murine models of arthritis.