Y
Yoann Rombouts
Researcher at University of Toulouse
Publications - 62
Citations - 3167
Yoann Rombouts is an academic researcher from University of Toulouse. The author has contributed to research in topics: Glycosylation & Antibody. The author has an hindex of 27, co-authored 58 publications receiving 2509 citations. Previous affiliations of Yoann Rombouts include University of Montpellier & university of lille.
Papers
More filters
Journal ArticleDOI
Regulation of autoantibody activity by the IL-23-T H 17 axis determines the onset of autoimmune disease.
R Pfeifle,Tobias Rothe,Natacha Ipseiz,Hans Scherer,Stephan Culemann,Ulrike Harre,Jochen A. Ackermann,Martina Seefried,Arnd Kleyer,Stefan Uderhardt,Benjamin Haugg,Axel J. Hueber,Patrick Daum,Gordon F. Heidkamp,Changrong Ge,Sybille Böhm,Anja Lux,Wolfgang Schuh,Iryna Magorivska,Kutty Selva Nandakumar,Erik Lönnblom,Christoph Becker,Diana Dudziak,Manfred Wuhrer,Yoann Rombouts,Yoann Rombouts,Yoann Rombouts,Carolien A. M. Koeleman,René E. M. Toes,Thomas Winkler,Rikard Holmdahl,Martin Herrmann,Stephan Blüml,Falk Nimmerjahn,Georg Schett,Gerhard Krönke +35 more
TL;DR: An IL-23–TH17 cell–dependent pathway is identified that controls autoantibody activity and unmasks a preexisting breach in immunotolerance in rheumatoid arthritis.
Journal ArticleDOI
Anti-citrullinated protein antibodies acquire a pro-inflammatory Fc glycosylation phenotype prior to the onset of rheumatoid arthritis
Yoann Rombouts,Ewoud Ewing,Lotte A van de Stadt,Maurice H. J. Selman,Leendert A. Trouw,André M. Deelder,Tom W J Huizinga,Manfred Wuhrer,Dirkjan van Schaardenburg,René E. M. Toes,Hans Scherer +10 more
TL;DR: Whether anticitrullinated protein antibodies (ACPA) exhibit specific changes in Fc glycosylation prior to the onset of arthritis is investigated to see if changes towards a more pro-inflammatory phenotype could be involved in driving the disease process.
Journal ArticleDOI
Immunoglobulin G (IgG) Fab Glycosylation Analysis Using a New Mass Spectrometric High-throughput Profiling Method Reveals Pregnancy-associated Changes
Albert Bondt,Albert Bondt,Yoann Rombouts,Maurice H. J. Selman,Paul J. Hensbergen,Karli R. Reiding,Johanna M. W. Hazes,Radboud J E M Dolhain,Manfred Wuhrer,Manfred Wuhrer,Manfred Wuhrer +10 more
TL;DR: The parallel analysis of IgG Fab and Fc, as set up in this paper, will be important for unraveling roles of these glycans in (auto)immunity, which may be mediated via recognition by human lectins or modulation of antigen binding.
Journal ArticleDOI
The Emerging Importance of IgG Fab Glycosylation in Immunity.
TL;DR: IgG Fab glycosylation appears to be an important, yet poorly understood, process that modulates immunity and is associated with the anti-inflammatory activity of IVIgs.
Journal ArticleDOI
Glycosylation of immunoglobulin G determines osteoclast differentiation and bone loss
Ulrike Harre,Stefanie C. Lang,R Pfeifle,Yoann Rombouts,Sabine Frühbeißer,Khaled Amara,Holger Bang,Anja Lux,Carolien A. M. Koeleman,Wolfgang Baum,Katharina Dietel,Franziska Gröhn,Vivianne Malmström,Lars Klareskog,Gerhard Krönke,Roland Kocijan,Falk Nimmerjahn,René E. M. Toes,Martin Herrmann,Hans Scherer,Georg Schett +20 more
TL;DR: It is demonstrated that desialylated, but not sialylation, immune complexes enhance osteoclastogenesis in vitro and in vivo and that mice treated with the sialic acid precursor N-acetylmannosamine are less susceptible to inflammatory bone loss.