Tobias Rothe

TL;DR: Analysis of macrophage subsets within joints reveals a population of CX3CR1+ tissue-resident macrophages that form a tight-junction-mediated barrier at the synovial lining, protecting the joint from the invasion of inflammatory cells.

TL;DR: An IL-23–TH17 cell–dependent pathway is identified that controls autoantibody activity and unmasks a preexisting breach in immunotolerance in rheumatoid arthritis.

TL;DR: An unexpected key role is reported for enzymatic lipid oxidation during the maintenance of self-tolerance in ACs, resulting in an aberrant phagocytosis of ACs by inflammatory monocytes, subsequent antigen presentation of AC-derived antigens, and a lupus-like autoimmune disease.

TL;DR: It is determined that 12/15-lipoxygenase-meditated (12/ 15-LO-mediated) enzymatic lipid oxidation regulates DC activation and fine-tunes consecutive T cell responses and implicate enzymatics lipid oxidation in shaping the adaptive immune response.

TL;DR: It is suggested that chronic peripheral inflammation has heterogeneous effects on the brain, as evidenced by the spectrum of myeloid cell responses observed across brain regions, which include induction of chemokines, complement factors, and endothelial adhesion molecules.