Kwangseok Hong

TL;DR: Data support that EC-MR plays a role in regulating endothelial function in hypertension and participates in regulation of vasomotor function in a vascular bed–specific manner that is also modulated by risk factors, such as hypertension.

TL;DR: SMC-MR regulation of miR-155, Cav1.2 and AgtR1 impacts vasoconstriction with aging is identified and potential new treatment strategies and biomarkers to improve and individualize antihypertensive therapy in the elderly are identified.

TL;DR: It is shown that Ca2+ influx through TRPV4 channels at myoendothelial projections to smooth muscle cells decreases resting blood pressure in nonobese mice, a response that is diminished in obese mice, suggesting that a spatially restricted impairment of endothelial TRPv4 channels contributes to obesity-induced hypertension and imply that inhibiting peroxynitrite might represent a strategy for normalizing endothelium TRP V4 channel activity, vasodilation, and blood pressure

TL;DR: Candesartan, an inverse agonist of the type 1 angiotensin II receptor (AT1R), causes a concentration‐dependent inhibition of pressure‐dependent myogenic tone consistent with previous reports of mechanosensitivity of this G protein‐coupled receptor.

TL;DR: A novel Ca2+ signaling mechanism that regulates endothelium‐dependent vasodilation in resistance‐sized PAs is reported and it is discovered that adenosine triphosphate dilates PAs through a P2 purinergic receptor‐dependent activation of TRPV4 sparklets.