L
L. Brix
Researcher at Max Planck Society
Publications - 13
Citations - 80
L. Brix is an academic researcher from Max Planck Society. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 3, co-authored 7 publications receiving 15 citations.
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Journal ArticleDOI
The co-chaperone Fkbp5 shapes the acute stress response in the paraventricular nucleus of the hypothalamus of male mice
Alexander S. Häusl,L. Brix,Jakob Hartmann,Max L. Pöhlmann,Juan-Pablo Lopez,Danusa Menegaz,Elena Brivio,Clara Engelhardt,Simone Roeh,Thomas Bajaj,Lisa Rudolph,Rainer Stoffel,Kathrin Hafner,Hannah M Goss,Johannes M. H. M. Reul,Jan M. Deussing,Matthias Eder,Kerry J. Ressler,Nils C. Gassen,Nils C. Gassen,Alon Chen,Alon Chen,Mathias V. Schmidt +22 more
TL;DR: In this article, a single-cell RNA sequencing revealed the cell-type-specific expression pattern of Fkbp5 in the paraventricular nucleus of the hypothalamus (PVN) in shaping HPA axis (re)activity.
Journal ArticleDOI
Chronic social defeat stress in female mice leads to sex-specific behavioral and neuroendocrine effects
Lotte van Doeselaar,Huanqing Yang,Joeri Bordes,L. Brix,Clara Engelhardt,Fiona Tang,Mathias V. Schmidt +6 more
TL;DR: There are differences in the way that female and male mice respond towards chronic social stress conditions when it comes to behavior and hormonal changes, which are partially dependent on estrous cycle stage.
Journal ArticleDOI
The co-chaperone FKBP51 modulates HPA axis activity and age-related maladaptation of the stress system in pituitary proopiomelanocortin cells
L. Brix,Alexander S. Häusl,Irmak Toksöz,Joeri Bordes,Lotte van Doeselaar,Clara Engelhardt,Sowmya V. Narayan,Margherita Springer,V. Sterlemann,Jan M. Deussing,Alon Chen,Mathias V. Schmidt +11 more
TL;DR: In this article , a combination of endogenous knockout and viral rescue was used to show that male mice lacking FKBP51 in Pomc-expressing cells exhibit enhanced glucocorticoid (GC)-mediated negative feedback and are protected from age-related disruption of their diurnal corticosterone (CORT) rhythm.
Posted ContentDOI
Mediobasal hypothalamic FKBP51 acts as a molecular switch linking autophagy to whole-body metabolism
Alexander S. Häusl,L. Brix,Thomas Bajaj,Max L. Pöhlmann,Kathrin Hafner,De Angelis M,Nagler J,Georgia Balsevich,Schramm K,Patrick Giavalisco,Alon Chen,Alon Chen,Mathias V. Schmidt,Nils C. Gassen,Nils C. Gassen +14 more
TL;DR: In this article, the FK506-binding protein 51 (FKBP51) is identified as a central nexus for the recruitment of the LKB1/AMPK complex to WIPI4 and TSC2 to WipI3, thereby regulating the balance between autophagy and mTOR signaling.
Posted ContentDOI
The co-chaperone Fkbp5 shapes the acute stress response in the paraventricular nucleus of the hypothalamus
Alexander S. Häusl,Jakob Hartmann,Max L. Pöhlmann,L. Brix,Juan-Pablo Lopez,Elena Brivio,Clara Engelhardt,Simone Roeh,Lisa Rudolph,Rainer Stoffel,Kathrin Hafner,Hannah M Goss,Johannes M. H. M. Reul,Jan M. Deussing,Kerry J. Ressler,Nils C. Gassen,Nils C. Gassen,Alon Chen,Mathias V. Schmidt +18 more
TL;DR: The fundamental importance of F kbp5 in the HPA axis stress response is established and it is shown that Fkbp5 manipulation alters GR activation and elucidate the cellular complexity in the PVN, in which FKBp5 operates.