S
Simone Roeh
Researcher at Max Planck Society
Publications - 14
Citations - 182
Simone Roeh is an academic researcher from Max Planck Society. The author has contributed to research in topics: Glucocorticoid receptor & Bisulfite sequencing. The author has an hindex of 5, co-authored 14 publications receiving 89 citations.
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Journal ArticleDOI
Identity domains capture individual differences from across the behavioral repertoire
Oren Forkosh,Stoyo Karamihalev,Stoyo Karamihalev,Simone Roeh,Uri Alon,Sergey Anpilov,Sergey Anpilov,Chadi Touma,Markus Nussbaumer,Cornelia Flachskamm,Paul M. Kaplick,Yair Shemesh,Yair Shemesh,Alon Chen,Alon Chen +14 more
TL;DR: A mathematical framework for describing individual differences along dimensions with maximum consistency and discriminative power is introduced and validated in mice, demonstrating a set of stable traits that capture variability in behavior and gene expression in the brain.
Journal ArticleDOI
The co-chaperone Fkbp5 shapes the acute stress response in the paraventricular nucleus of the hypothalamus of male mice
Alexander S. Häusl,L. Brix,Jakob Hartmann,Max L. Pöhlmann,Juan-Pablo Lopez,Danusa Menegaz,Elena Brivio,Clara Engelhardt,Simone Roeh,Thomas Bajaj,Lisa Rudolph,Rainer Stoffel,Kathrin Hafner,Hannah M Goss,Johannes M. H. M. Reul,Jan M. Deussing,Matthias Eder,Kerry J. Ressler,Nils C. Gassen,Nils C. Gassen,Alon Chen,Alon Chen,Mathias V. Schmidt +22 more
TL;DR: In this article, a single-cell RNA sequencing revealed the cell-type-specific expression pattern of Fkbp5 in the paraventricular nucleus of the hypothalamus (PVN) in shaping HPA axis (re)activity.
Journal ArticleDOI
Single-cell molecular profiling of all three components of the HPA axis reveals adrenal ABCB1 as a regulator of stress adaptation.
Juan Pablo Lopez,Juan Pablo Lopez,Elena Brivio,Elena Brivio,Alice Santambrogio,Alice Santambrogio,Carlo De Donno,Carlo De Donno,Aron Kos,Aron Kos,Miriam Peters,Nicolas Rost,Darina Czamara,Tanja Brückl,Simone Roeh,Max L. Pöhlmann,Clara Engelhardt,Andrea Ressle,Rainer Stoffel,Alina Tontsch,Javier M. Villamizar,Martin Reincke,Anna Riester,Silviu Sbiera,Martin Fassnacht,Helen S. Mayberg,W. Edward Craighead,Boadie W. Dunlop,Charles B. Nemeroff,Mathias V. Schmidt,Elisabeth B. Binder,Fabian J. Theis,Felix Beuschlein,Cynthia L. Andoniadou,Cynthia L. Andoniadou,Alon Chen,Alon Chen +36 more
TL;DR: In this paper, the authors provided the first unbiased, cell type-specific, molecular characterization of all three components of the hypothalamic-pituitary-adrenal axis, under baseline and chronic stress conditions.
Journal ArticleDOI
HAM-TBS: high-accuracy methylation measurements via targeted bisulfite sequencing.
Simone Roeh,Tobias Wiechmann,Susann Sauer,Maik Ködel,Elisabeth B. Binder,Elisabeth B. Binder,Nadine Provencal,Nadine Provencal,Nadine Provencal +8 more
TL;DR: HAM-TBS represents a highly accurate, medium-throughput sequencing approach for robust detection of DNA methylation changes in specific target regions and designed and validated a targeted panel to specifically assess regulatory regions within the FKBP5 locus that are not covered in commercially availableDNA methylation arrays.
Posted ContentDOI
The role of m6A-RNA methylation in stress response regulation
Mareen Engel,Simone Roeh,Carola Eggert,Paul M. Kaplick,Lisa Tietze,Janine Arloth,Peter Weber,Monika Rex-Haffner,Mira Jakovcevski,Manfred Uhr,Matthias Eder,Carsten T. Wotjak,Mathias V. Schmidt,Jan M. Deussing,Elisabeth B. Binder,Alon Chen +15 more
TL;DR: It is demonstrated that depletion of the methyltransferase Mettl3 and the demethylase Fto in adult neurons increases fear memory, and alters the transcriptome response to fear as well as synaptic plasticity, and regulation of m6A is impaired in major depressive disorder patients following glucocorticoid receptor activation.