L
L. Julie Huber
Researcher at Cornell University
Publications - 9
Citations - 1790
L. Julie Huber is an academic researcher from Cornell University. The author has contributed to research in topics: Neurotrophin & Receptor. The author has an hindex of 6, co-authored 9 publications receiving 1737 citations.
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Journal ArticleDOI
Targeted mutation of the gene encoding the low affinity NGF receptor p75 leads to deficits in the peripheral sensory nervous system.
Kuo-Fen Lee,En Li,L. Julie Huber,Story C. Landis,Arlene H. Sharpe,Moses V. Chao,Rudolf Jaenisch +6 more
TL;DR: In this article, a mouse carrying a mutation of the gene encoding the low affinity NGF receptor p75NGFR was generated by targeted mutation in embryonic stem cells and the defective innervation was correlated with loss of heat sensitivity and associated with the development of ulcers in the distal extremities.
Journal ArticleDOI
Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage.
Jonathan M. Solomon,Rao Pasupuleti,Lei Xu,Thomas McDonagh,Rory A. J. Curtis,Peter S. DiStefano,L. Julie Huber +6 more
TL;DR: Results show that, although SIRT1 deacetylates p53, this does not play a role in cell survival following DNA damage in certain cell lines and primary human mammary epithelial cells.
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Differential role of the low affinity neurotrophin receptor (p75) in retrograde axonal transport of the neurotrophins.
Rory A. J. Curtis,Krystyna M. Adryan,Jennifer L. Stark,John S. Park,Debra L Compton,Gisela Weskamp,L. Julie Huber,Moses V. Chao,Rudolf Jaenisch,Kuo-Fen Lee,Ronald M. Lindsay,Peter S. DiStefano +11 more
TL;DR: A selective role for LNR is demonstrated in retrograde transport of the various neurotrophins from distinct target regions in vivo.
Journal ArticleDOI
Mesenchymal and Neuronal Cell Expression of the p75 Neurotrophin Receptor Gene Occur by Different Mechanisms
L. Julie Huber,Moses V. Chao +1 more
TL;DR: The detection of p75 receptors in the mesenchyme implies that neurotrophins are likely to exert effects during morphogenesis of mesodermal tissues and that separate signals arelikely to direct neuronal versus nonneuronal expression of the p75 gene.