T
Tomas Novak
Researcher at Charles University in Prague
Publications - 121
Citations - 4242
Tomas Novak is an academic researcher from Charles University in Prague. The author has contributed to research in topics: Bipolar disorder & Transcranial magnetic stimulation. The author has an hindex of 30, co-authored 120 publications receiving 3630 citations. Previous affiliations of Tomas Novak include National Institutes of Health & Eli Lilly and Company.
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Journal ArticleDOI
Assessment of Response to Lithium Maintenance Treatment in Bipolar Disorder: A Consortium on Lithium Genetics (ConLiGen) Report
Mirko Manchia,Mazda Adli,Nirmala Akula,Raffaella Ardau,Jean-Michel Aubry,Lena Backlund,Claudio E. M. Banzato,Bernhard T. Baune,Frank Bellivier,Susanne Bengesser,Joanna M. Biernacka,Clara Brichant-Petitjean,Elise Bui,Cynthia V. Calkin,Andrew T. A. Cheng,Caterina Chillotti,Sven Cichon,Scott R. Clark,Piotr M. Czerski,Clarissa de Rosalmeida Dantas,Maria Del Zompo,J. Raymond DePaulo,Sevilla D. Detera-Wadleigh,Bruno Etain,Peter Falkai,Louise Frisén,Mark A. Frye,Janice M. Fullerton,Sébastien Gard,Julie Garnham,Fernando S. Goes,Paul Grof,Oliver Gruber,Ryota Hashimoto,Joanna Hauser,Urs Heilbronner,Rebecca Hoban,Rebecca Hoban,Liping Hou,Stéphane Jamain,Jean-Pierre Kahn,Layla Kassem,Tadafumi Kato,John R. Kelsoe,John R. Kelsoe,Sarah Kittel-Schneider,Sebastian Kliwicki,Po-Hsiu Kuo,Ichiro Kusumi,Gonzalo Laje,Catharina Lavebratt,Marion Leboyer,Susan G. Leckband,Susan G. Leckband,Carlos Jaramillo,Mario Maj,Alain Malafosse,Lina Martinsson,Takuya Masui,Philip B. Mitchell,Frank Mondimore,Palmiero Monteleone,Audrey Nallet,Maria Neuner,Tomas Novak,Claire O'Donovan,Urban Ösby,Norio Ozaki,Norio Ozaki,Roy H. Perlis,Andrea Pfennig,James B. Potash,James B. Potash,Daniela Reich-Erkelenz,Andreas Reif,Eva Z. Reininghaus,Sara Richardson,Guy A. Rouleau,Janusz K. Rybakowski,Martin Schalling,Peter R. Schofield,O. Schubert,Barbara W. Schweizer,Florian Seemüller,Maria Grigoroiu-Serbanescu,Giovanni Severino,Lisa R. Seymour,Claire Slaney,Jordan W. Smoller,Alessio Squassina,Thomas Stamm,Jo Steele,Pavla Stopkova,Sarah K. Tighe,Alfonso Tortorella,Gustavo Turecki,Naomi R. Wray,Adam Wright,Peter P. Zandi,David Zilles,Michael Bauer,Marcella Rietschel,Francis J. McMahon,Thomas G. Schulze,Martin Alda +104 more
TL;DR: The key phenotypic measures of the “Retrospective Criteria of Long-Term Treatment Response in Research Subjects with Bipolar Disorder” scale currently used in the Consortium on lithium Genetics (ConLiGen) study are reported.
Journal ArticleDOI
Genetic variants associated with response to lithium treatment in bipolar disorder: a genome-wide association study
Liping Hou,Urs Heilbronner,Urs Heilbronner,Franziska Degenhardt,Mazda Adli,Kazufumi Akiyama,Nirmala Akula,Raffaella Ardau,Bárbara Arias,Lena Backlund,Claudio E. M. Banzato,Antoni Benabarre,Susanne Bengesser,Abesh Kumar Bhattacharjee,Joanna M. Biernacka,Armin Birner,Clara Brichant-Petitjean,Elise T. Bui,Pablo Cervantes,Guo-Bo Chen,Hsi-Chung Chen,Caterina Chillotti,Sven Cichon,Sven Cichon,Scott R. Clark,Francesc Colom,David A. Cousins,Cristiana Cruceanu,Piotr M. Czerski,Clarissa de Rosalmeida Dantas,Alexandre Dayer,Bruno Etain,Peter Falkai,Andreas J. Forstner,Louise Frisén,Janice M. Fullerton,Janice M. Fullerton,Sébastien Gard,Julie Garnham,Fernando S. Goes,Paul Grof,Oliver Gruber,Ryota Hashimoto,Joanna Hauser,Stefan Herms,Stefan Herms,Per Hoffmann,Per Hoffmann,Andrea Hofmann,Stéphane Jamain,Esther Jiménez,Jean-Pierre Kahn,Layla Kassem,Sarah Kittel-Schneider,Sebastian Kliwicki,Barbara König,Ichiro Kusumi,N. Lackner,Gonzalo Laje,Mikael Landén,Mikael Landén,Catharina Lavebratt,Marion Leboyer,Susan G. Leckband,Susan G. Leckband,Carlos Jaramillo,Glenda MacQueen,Mirko Manchia,Mirko Manchia,Lina Martinsson,Manuel Mattheisen,Michael McCarthy,Susan L. McElroy,Marina Mitjans,Francis M. Mondimore,Palmiero Monteleone,Palmiero Monteleone,Caroline M. Nievergelt,Markus M. Nöthen,Urban Ösby,Norio Ozaki,Roy H. Perlis,Andrea Pfennig,Daniela Reich-Erkelenz,Guy A. Rouleau,Peter R. Schofield,Peter R. Schofield,K Oliver Schubert,Barbara W. Schweizer,Florian Seemüller,Giovanni Severino,Tatyana Shekhtman,Tatyana Shekhtman,Paul D. Shilling,Kazutaka Shimoda,Christian Simhandl,Claire Slaney,Jordan W. Smoller,Alessio Squassina,Thomas Stamm,Pavla Stopkova,Sarah K. Tighe,Sarah K. Tighe,Alfonso Tortorella,Gustavo Turecki,Julia Volkert,Stephanie H. Witt,Adam Wright,L. Trevor Young,Peter P. Zandi,James B. Potash,J. Raymond DePaulo,Michael Bauer,Eva Z. Reininghaus,Tomas Novak,Jean-Michel Aubry,Mario Maj,Bernhard T. Baune,Philip B. Mitchell,Eduard Vieta,Mark A. Frye,Janusz K. Rybakowski,Po-Hsiu Kuo,Tadafumi Kato,Maria Grigoroiu-Serbanescu,Andreas Reif,Maria Del Zompo,Frank Bellivier,Martin Schalling,Naomi R. Wray,John R. Kelsoe,John R. Kelsoe,Martin Alda,Martin Alda,Marcella Rietschel,Francis J. McMahon,Thomas G. Schulze +136 more
TL;DR: A genome-wide association study of lithium response in 2,563 patients collected by 22 participating sites from the International Consortium on Lithium Genetics (ConLiGen); the largest attempted so far finds a single locus of four linked SNPs on chromosome 21 met genome- wide significance criteria for association with lithium response.
Journal ArticleDOI
Genome-wide association study of 40,000 individuals identifies two novel loci associated with bipolar disorder.
Liping Hou,Sarah E. Bergen,Sarah E. Bergen,Nirmala Akula,Jie Song,Christina M. Hultman,Mikael Landén,Mikael Landén,Mazda Adli,Martin Alda,Raffaella Ardau,Bárbara Arias,Jean-Michel Aubry,Lena Backlund,Judith A. Badner,Thomas B. Barrett,Michael Bauer,Bernhard T. Baune,Frank Bellivier,Antonio Benabarre,Susanne Bengesser,Wade H. Berrettini,Abesh Kumar Bhattacharjee,Joanna M. Biernacka,Armin Birner,Cinnamon S. Bloss,Clara Brichant-Petitjean,Elise T. Bui,William Byerley,Pablo Cervantes,Caterina Chillotti,Sven Cichon,Sven Cichon,Francesc Colom,William Coryell,David Craig,Cristiana Cruceanu,Piotr M. Czerski,Tony Davis,Alexandre Dayer,Franziska Degenhardt,Maria Del Zompo,J. Raymond DePaulo,Howard J. Edenberg,Bruno Etain,Peter Falkai,Tatiana Foroud,Andreas J. Forstner,Louise Frisén,Mark A. Frye,Janice M. Fullerton,Janice M. Fullerton,Sébastien Gard,Julie Garnham,Elliot S. Gershon,Fernando S. Goes,Tiffany A. Greenwood,Maria Grigoroiu-Serbanescu,Joanna Hauser,Urs Heilbronner,Urs Heilbronner,Stefanie Heilmann-Heimbach,Stefan Herms,Stefan Herms,Maria Hipolito,Shashi Hitturlingappa,Per Hoffmann,Per Hoffmann,Andrea Hofmann,Stéphane Jamain,Esther Jiménez,Jean-Pierre Kahn,Layla Kassem,John R. Kelsoe,Sarah Kittel-Schneider,Sebastian Kliwicki,Daniel L. Koller,Barbara König,N. Lackner,Gonzalo Laje,Maren Lang,Catharina Lavebratt,William Lawson,Marion Leboyer,Susan G. Leckband,Chunyu Liu,Anna Maaser,Pamela B. Mahon,Wolfgang Maier,Mario Maj,Mirko Manchia,Mirko Manchia,Lina Martinsson,Michael McCarthy,Susan L. McElroy,Melvin G. McInnis,Rebecca McKinney,Philip B. Mitchell,Marina Mitjans,Francis M. Mondimore,Palmiero Monteleone,Palmiero Monteleone,Thomas W. Mühleisen,Caroline M. Nievergelt,Markus M. Nöthen,Tomas Novak,John I. Nurnberger,Evaristus A. Nwulia,Urban Ösby,Andrea Pfennig,James B. Potash,Peter Propping,Andreas Reif,Eva Z. Reininghaus,John P. Rice,Marcella Rietschel,Guy A. Rouleau,Janusz K. Rybakowski,Martin Schalling,William A. Scheftner,Peter R. Schofield,Peter R. Schofield,Nicholas J. Schork,Thomas G. Schulze,Johannes Schumacher,Barbara W. Schweizer,Giovanni Severino,Tatyana Shekhtman,Paul D. Shilling,Christian Simhandl,Claire Slaney,Erin N. Smith,Alessio Squassina,Thomas Stamm,Pavla Stopkova,Fabian Streit,Jana Strohmaier,Szabolcs Szelinger,Sarah K. Tighe,Alfonso Tortorella,Gustavo Turecki,Eduard Vieta,Julia Volkert,Stephanie H. Witt,Adam Wright,Peter P. Zandi,Peng Zhang,Sebastian Zöllner,Francis J. McMahon +148 more
TL;DR: A two-stage meta-analysis of GWAS of bipolar disorder patients and controls revealed genome-wide significant associations at two novel loci, adding to a growing list of common autosomal variants involved in BD and illustrating the power of comparing well-characterized cases to an excess of controls in GWAS.
Journal Article
Relationship of ketamine's antidepressant and psychotomimetic effects in unipolar depression.
TL;DR: A substantial relationship between ketamine's antidepressant and psychotomimetic effects was found, and this relationship could be mediated by the initial steps of ketamine’s action, trough NMDA receptors, shared by both ketamines' clinical effects.
Journal ArticleDOI
Increase in GSK3β gene copy number variation in bipolar disorder
Herbert M. Lachman,Erika Pedrosa,Oriana A. Petruolo,Melissa S. Cockerham,Alexander Papolos,Tomas Novak,Demitri F. Papolos,Pavla Stopkova +7 more
TL;DR: Patients with BD have an increased frequency of this CNV—primarily the duplication variant—compared with controls, which suggests that GSK3β may be involved in BD susceptibility in some individuals and that CNVs in this and other candidate genes for psychiatric disorders should be analyzed as causative functional genetic variants.