L
Laila Mselli-Lakhal
Researcher at University of Toulouse
Publications - 23
Citations - 1436
Laila Mselli-Lakhal is an academic researcher from University of Toulouse. The author has contributed to research in topics: Constitutive androstane receptor & Lipogenesis. The author has an hindex of 12, co-authored 21 publications receiving 1063 citations. Previous affiliations of Laila Mselli-Lakhal include Institut national de la recherche agronomique & Paul Sabatier University.
Papers
More filters
Journal ArticleDOI
Liver PPARα is crucial for whole-body fatty acid homeostasis and is protective against NAFLD
Alexandra Montagner,Arnaud Polizzi,Edwin Fouché,Simon Ducheix,Yannick Lippi,Frédéric Lasserre,Valentin Barquissau,Valentin Barquissau,Marion Régnier,Céline Lukowicz,Fadila Benhamed,Fadila Benhamed,Fadila Benhamed,Alison Iroz,Alison Iroz,Alison Iroz,Justine Bertrand-Michel,Justine Bertrand-Michel,Talal Al Saati,Patricia Cano,Laila Mselli-Lakhal,Gilles Mithieux,Fabienne Rajas,Sandrine Lagarrigue,Sandrine Lagarrigue,Sandrine Lagarrigue,Thierry Pineau,Nicolas Loiseau,Catherine Postic,Catherine Postic,Catherine Postic,Dominique Langin,Dominique Langin,Dominique Langin,Walter Wahli,Walter Wahli,Walter Wahli,Hervé Guillou +37 more
TL;DR: Hepatocyte PPARα deletion impaired fatty acid catabolism, resulting in hepatic lipid accumulation during fasting and in two preclinical models of steatosis, underscore the potential of hepatocyte PParα as a drug target for NAFLD.
Journal ArticleDOI
Low doses of bisphenol A induce gene expression related to lipid synthesis and trigger triglyceride accumulation in adult mouse liver.
A. Marmugi,Simon Ducheix,Simon Ducheix,Frédéric Lasserre,Frédéric Lasserre,Arnaud Polizzi,Arnaud Polizzi,Alain Paris,Nathalie Priymenko,Nathalie Priymenko,Justine Bertrand-Michel,Thierry Pineau,Thierry Pineau,Hervé Guillou,Hervé Guillou,Pascal G.P. Martin,Pascal G.P. Martin,Laila Mselli-Lakhal,Laila Mselli-Lakhal +18 more
TL;DR: Exposure to low BPA doses may influence de novo fatty acid synthesis through increased expression of lipogenic genes, thereby contributing to hepatic steatosis.
Journal ArticleDOI
Low doses of Bisphenol A induce gene expression related to lipid synthesis and trigger triglyceride accumulation in adult mouse liver
A. Marmugi,M.-S. Ducheix,M.-F. Lasserre,M.A. Polizzi,Alain Paris,Nathalie Priymenko,Justine Bertrand-Michel,Thierry Pineau,Hervé Guillou,Pascal G.P. Martin,Laila Mselli-Lakhal +10 more
TL;DR: The objective of this study was to establish a baseline level of understanding of lipid Metabolism and cancerigenicity that is compatible withacceptably high levels ofresearch into these topics.
Journal ArticleDOI
Metabolic Effects of a Chronic Dietary Exposure to a Low-Dose Pesticide Cocktail in Mice: Sexual Dimorphism and Role of the Constitutive Androstane Receptor
Céline Lukowicz,Sandrine Ellero-Simatos,Marion Régnier,Arnaud Polizzi,Frédéric Lasserre,Alexandra Montagner,Yannick Lippi,Emilien L. Jamin,Jean-François Martin,Claire Naylies,Cécile Canlet,Laurent Debrauwer,Justine Bertrand-Michel,Talal Al Saati,Vassilia Theodorou,Nicolas Loiseau,Laila Mselli-Lakhal,Hervé Guillou,Laurence Gamet-Payrastre +18 more
TL;DR: This work is the first to demonstrate a sexually dimorphic obesogenic and diabetogenic effect of chronic dietary exposure to a common mixture of pesticides at TDI levels, and to provide evidence for a partial role for CAR in an in vivo mouse model, and raises questions about the relevance of TDI for individual pesticides when present in a mixture.
Journal ArticleDOI
Adverse effects of long-term exposure to bisphenol A during adulthood leading to hyperglycaemia and hypercholesterolemia in mice.
Alice Marmugi,Frédéric Lasserre,Diane Beuzelin,Simon Ducheix,Laurence Huc,Arnaud Polizzi,Maud Chetivaux,Thierry Pineau,Pascal G.P. Martin,Hervé Guillou,Laila Mselli-Lakhal,Laila Mselli-Lakhal +11 more
TL;DR: The effect of several months of BPA exposure on hepatic and plasma metabolic markers in adult mice is investigated and results are consistent with many epidemiological studies reporting on a link between BPA Exposure and the onset of cardiovascular diseases.