N
Nicolas Loiseau
Researcher at University of Toulouse
Publications - 63
Citations - 2503
Nicolas Loiseau is an academic researcher from University of Toulouse. The author has contributed to research in topics: Fatty liver & Fumonisin B1. The author has an hindex of 23, co-authored 55 publications receiving 1779 citations. Previous affiliations of Nicolas Loiseau include Paul Sabatier University & University of California, San Francisco.
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Journal ArticleDOI
Liver PPARα is crucial for whole-body fatty acid homeostasis and is protective against NAFLD
Alexandra Montagner,Arnaud Polizzi,Edwin Fouché,Simon Ducheix,Yannick Lippi,Frédéric Lasserre,Valentin Barquissau,Valentin Barquissau,Marion Régnier,Céline Lukowicz,Fadila Benhamed,Fadila Benhamed,Fadila Benhamed,Alison Iroz,Alison Iroz,Alison Iroz,Justine Bertrand-Michel,Justine Bertrand-Michel,Talal Al Saati,Patricia Cano,Laila Mselli-Lakhal,Gilles Mithieux,Fabienne Rajas,Sandrine Lagarrigue,Sandrine Lagarrigue,Sandrine Lagarrigue,Thierry Pineau,Nicolas Loiseau,Catherine Postic,Catherine Postic,Catherine Postic,Dominique Langin,Dominique Langin,Dominique Langin,Walter Wahli,Walter Wahli,Walter Wahli,Hervé Guillou +37 more
TL;DR: Hepatocyte PPARα deletion impaired fatty acid catabolism, resulting in hepatic lipid accumulation during fasting and in two preclinical models of steatosis, underscore the potential of hepatocyte PParα as a drug target for NAFLD.
Journal ArticleDOI
Toxicology of deoxynivalenol and its acetylated and modified forms
Delphine Payros,Imourana Alassane-Kpembi,Alix Pierron,Nicolas Loiseau,Philippe Pinton,Isabelle P. Oswald +5 more
TL;DR: The toxic effects of deoxynivalenol include emesis and anorexia, alteration of intestinal and immune functions, reduced absorption of the nutrients as well as increased susceptibility to infection and chronic diseases.
Journal ArticleDOI
The Mycotoxin Fumonisin B1 Alters the Proliferation and the Barrier Function of Porcine Intestinal Epithelial Cells
Sandrine Bouhet,Edith Hourcade,Nicolas Loiseau,Asmaa Fikry,Stéphanie Martinez,Marianna Roselli,Pierre Galtier,Elena Mengheri,Isabelle P. Oswald +8 more
TL;DR: Data indicate that FB1 alters the proliferation and the barrier function of intestinal cells, and the effects of FB1 on the integrity of the barrier formed by the intestinal epithelium may have implications for humans and animals consuming FB1-contaminated food or feed.
Journal ArticleDOI
Microbial biotransformation of DON: molecular basis for reduced toxicity
Alix Pierron,Sabria Mimoun,Leticia S. Murate,Leticia S. Murate,Nicolas Loiseau,Yannick Lippi,Ana Paula Frederico Rodrigues Loureiro Bracarense,Gerd Schatzmayr,Jian Wei He,Ting Zhou,Wulf-Dieter Moll,Isabelle P. Oswald +11 more
TL;DR: It is demonstrated that bacterial de-epoxidation or epimerization of DON altered their interaction with the ribosome, leading to an absence of MAPKinase activation and a reduced toxicity.
Journal ArticleDOI
Characterization of two pharmacophores on the multidrug transporter P-glycoprotein.
Alexia Garrigues,Nicolas Loiseau,Marcel Delaforge,Jacques Ferte,Manuel Garrigos,François André,Stéphane Orlowski +6 more
TL;DR: The molecular characteristics involved in the binding selectivity of P-glycoprotein are investigated by means of a molecular modeling approach using various substrates combined with an enzymological study using these substrates and native membrane vesicles prepared from MDR cells.