L
Larissa G.P. Langhi
Researcher at Mayo Clinic
Publications - 3
Citations - 1562
Larissa G.P. Langhi is an academic researcher from Mayo Clinic. The author has contributed to research in topics: Senolytic & Neurogenesis. The author has an hindex of 3, co-authored 3 publications receiving 913 citations.
Papers
More filters
Journal ArticleDOI
Senolytics improve physical function and increase lifespan in old age
Ming Xu,Ming Xu,Tamar Pirtskhalava,Joshua N. Farr,Bettina M. Weigand,Bettina M. Weigand,Allyson K. Palmer,Megan M. Weivoda,Christina L. Inman,Mikolaj Ogrodnik,Mikolaj Ogrodnik,Christine M Hachfeld,Daniel G. Fraser,Jennifer L Onken,Kurt O. Johnson,Grace C Verzosa,Larissa G.P. Langhi,Moritz Weigl,Nino Giorgadze,Nathan K. LeBrasseur,Jordan D. Miller,Diana Jurk,Ravinder J. Singh,David B. Allison,David B. Allison,Keisuke Ejima,Keisuke Ejima,Gene B. Hubbard,Yuji Ikeno,Yuji Ikeno,Hajrunisa Cubro,Vesna D. Garovic,Xiaonan Hou,S. John Weroha,Paul D. Robbins,Laura J. Niedernhofer,Sundeep Khosla,Tamara Tchkonia,James L. Kirkland +38 more
TL;DR: It is demonstrated that transplanting relatively small numbers of senescent cells into young mice is sufficient to cause persistent physical dysfunction, as well as to spread cellular senescence to host tissues, and a senolytic can reverse this dysfunction and potently increase lifespan in aged mice.
Journal ArticleDOI
Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis
Mikolaj Ogrodnik,Mikolaj Ogrodnik,Yi Zhu,Larissa G.P. Langhi,Tamar Tchkonia,Patrick Krüger,Edward Fielder,Stella Victorelli,Rifqha A. Ruswhandi,Nino Giorgadze,Tamar Pirtskhalava,Oleg Podgorni,Grigori Enikolopov,Kurt O. Johnson,Ming Xu,Christine Inman,Allyson K. Palmer,Marissa J. Schafer,Moritz Weigl,Yuji Ikeno,Terry C. Burns,João F. Passos,João F. Passos,Thomas von Zglinicki,Thomas von Zglinicki,James L. Kirkland,Diana Jurk,Diana Jurk +27 more
TL;DR: It is found that obesity results in the accumulation of senescent glial cells in proximity to the lateral ventricle, a region in which adult neurogenesis occurs, and that senolytics are a potential new therapeutic avenue for treating neuropsychiatric disorders.
Journal ArticleDOI
Erratum: Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis (Cell Metabolism (2019) 29(5) (1061–1077.e8), (S1550413118307459), (10.1016/j.cmet.2018.12.008))
Mikolaj Ogrodnik,Yi Zhu,Larissa G.P. Langhi,Tamar Tchkonia,Patrick Krüger,Edward Fielder,Stella Victorelli,Rifqha A. Ruswhandi,Nino Giorgadze,Tamar Pirtskhalava,Oleg Podgorni,Grigori Enikolopov,Kurt O. Johnson,Ming Xu,Christine Inman,Allyson K. Palmer,Marissa J. Schafer,Moritz Weigl,Yuji Ikeno,Terry C. Burns,João F. Passos,Thomas von Zglinicki,James L. Kirkland,Diana Jurk +23 more