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Keisuke Ejima
Researcher at Indiana University
Publications - 92
Citations - 2869
Keisuke Ejima is an academic researcher from Indiana University. The author has contributed to research in topics: Medicine & Viral load. The author has an hindex of 17, co-authored 80 publications receiving 1703 citations. Previous affiliations of Keisuke Ejima include University of Hong Kong & University of Alabama at Birmingham.
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Journal ArticleDOI
Senolytics improve physical function and increase lifespan in old age
Ming Xu,Ming Xu,Tamar Pirtskhalava,Joshua N. Farr,Bettina M. Weigand,Bettina M. Weigand,Allyson K. Palmer,Megan M. Weivoda,Christina L. Inman,Mikolaj Ogrodnik,Mikolaj Ogrodnik,Christine M Hachfeld,Daniel G. Fraser,Jennifer L Onken,Kurt O. Johnson,Grace C Verzosa,Larissa G.P. Langhi,Moritz Weigl,Nino Giorgadze,Nathan K. LeBrasseur,Jordan D. Miller,Diana Jurk,Ravinder J. Singh,David B. Allison,David B. Allison,Keisuke Ejima,Keisuke Ejima,Gene B. Hubbard,Yuji Ikeno,Yuji Ikeno,Hajrunisa Cubro,Vesna D. Garovic,Xiaonan Hou,S. John Weroha,Paul D. Robbins,Laura J. Niedernhofer,Sundeep Khosla,Tamara Tchkonia,James L. Kirkland +38 more
TL;DR: It is demonstrated that transplanting relatively small numbers of senescent cells into young mice is sufficient to cause persistent physical dysfunction, as well as to spread cellular senescence to host tissues, and a senolytic can reverse this dysfunction and potently increase lifespan in aged mice.
Journal ArticleDOI
Incubation period as part of the case definition of severe respiratory illness caused by a novel coronavirus.
Hiroshi Nishiura,Kenji Mizumoto,Kenji Mizumoto,Keisuke Ejima,Y. Zhong,Benjamin J. Cowling,Ryosuke Omori +6 more
TL;DR: It is worth including the incubation period in the case definition of novel coronavirus infection, and up to two days is suggestive of influenza.
Journal ArticleDOI
Senolytics reduce coronavirus-related mortality in old mice.
Christina D. Camell,Matthew J. Yousefzadeh,Yi Zhu,Larissa G.P. Langhi Prata,Matthew A. Huggins,Mark Pierson,Lei Zhang,Ryan D. O’Kelly,Tamar Pirtskhalava,Pengcheng Xun,Keisuke Ejima,Ailing Xue,Utkarsh Tripathi,Jair Machado Espindola-Netto,Nino Giorgadze,Elizabeth J. Atkinson,Christina L. Inman,Kurt O. Johnson,Stephanie H. Cholensky,Timothy W. Carlson,Nathan K. LeBrasseur,Sundeep Khosla,M. Gerard O'Sullivan,David B. Allison,Stephen C. Jameson,Alexander Meves,Ming Li,Y. S. Prakash,Sergio E. Chiarella,Sara E. Hamilton,Tamara Tchkonia,Laura J. Niedernhofer,James L. Kirkland,Paul D. Robbins +33 more
TL;DR: In this paper, the authors demonstrate that senescent cells become hyper-inflammatory in response to pathogen-associated molecular patterns (PAMPs), including SARS-CoV-2 spike protein-1, increasing expression of viral entry proteins and reducing antiviral gene expression in non-SnCs through a paracrine mechanism.
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Potential anti-COVID-19 agents, Cepharanthine and Nelfinavir, and their usage for combination treatment.
Hirofumi Ohashi,Hirofumi Ohashi,Koichi Watashi,Wakana Saso,Wakana Saso,Kaho Shionoya,Kaho Shionoya,Shoya Iwanami,Takatsugu Hirokawa,Takatsugu Hirokawa,Tsuyoshi Shirai,Shigehiko Kanaya,Yusuke Ito,Kwang Su Kim,Takao Nomura,Tateki Suzuki,Kazane Nishioka,Kazane Nishioka,Shuji Ando,Keisuke Ejima,Yoshiki Koizumi,Tomohiro Tanaka,Shin Aoki,Kouji Kuramochi,Tadaki Suzuki,Takao Hashiguchi,Katsumi Maenaka,Tetsuro Matano,Tetsuro Matano,Masamichi Muramatsu,Masayuki Saijo,Kazuyuki Aihara,Shingo Iwami,Makoto Takeda,Jane A. McKeating,Takaji Wakita +35 more
TL;DR: In this article, a panel of already approved drugs in a cell culture model of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and identified two new agents having higher antiviral potentials than the drug candidates such as remdesivir and chroloquine in VeroE6/TMPRSS2 cells: the anti-inflammatory drug cepharanthine and human immunodeficiency virus protease inhibitor nelfinavir.
Journal ArticleDOI
A quantitative model used to compare within-host SARS-CoV-2, MERS-CoV, and SARS-CoV dynamics provides insights into the pathogenesis and treatment of SARS-CoV-2.
Kwang Su Kim,Keisuke Ejima,Shoya Iwanami,Yasuhisa Fujita,Hirofumi Ohashi,Yoshiki Koizumi,Yusuke Asai,Shinji Nakaoka,Koichi Watashi,Koichi Watashi,Kazuyuki Aihara,Robin N Thompson,Ruian Ke,Alan S. Perelson,Shingo Iwami,Shingo Iwami,Shingo Iwami +16 more
TL;DR: In this paper, the authors compared within-host viral dynamics of SARS-CoV-2 infection with analogous dynamics of MERS and SARS CoV and found that the within host reproduction number at symptom onset was statistically significantly larger than MERS-coV and similar to SARS coV.