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Bettina M. Weigand
Researcher at Mayo Clinic
Publications - 3
Citations - 1380
Bettina M. Weigand is an academic researcher from Mayo Clinic. The author has contributed to research in topics: Senolytic & Senescence. The author has an hindex of 3, co-authored 3 publications receiving 757 citations. Previous affiliations of Bettina M. Weigand include Newcastle University.
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Journal ArticleDOI
Senolytics improve physical function and increase lifespan in old age
Ming Xu,Ming Xu,Tamar Pirtskhalava,Joshua N. Farr,Bettina M. Weigand,Bettina M. Weigand,Allyson K. Palmer,Megan M. Weivoda,Christina L. Inman,Mikolaj Ogrodnik,Mikolaj Ogrodnik,Christine M Hachfeld,Daniel G. Fraser,Jennifer L Onken,Kurt O. Johnson,Grace C Verzosa,Larissa G.P. Langhi,Moritz Weigl,Nino Giorgadze,Nathan K. LeBrasseur,Jordan D. Miller,Diana Jurk,Ravinder J. Singh,David B. Allison,David B. Allison,Keisuke Ejima,Keisuke Ejima,Gene B. Hubbard,Yuji Ikeno,Yuji Ikeno,Hajrunisa Cubro,Vesna D. Garovic,Xiaonan Hou,S. John Weroha,Paul D. Robbins,Laura J. Niedernhofer,Sundeep Khosla,Tamara Tchkonia,James L. Kirkland +38 more
TL;DR: It is demonstrated that transplanting relatively small numbers of senescent cells into young mice is sufficient to cause persistent physical dysfunction, as well as to spread cellular senescence to host tissues, and a senolytic can reverse this dysfunction and potently increase lifespan in aged mice.
Journal ArticleDOI
Whole-body senescent cell clearance alleviates age-related brain inflammation and cognitive impairment in mice
Mikolaj Ogrodnik,Shane A. Evans,Edward Fielder,Stella Victorelli,Patrick Krüger,Hanna Salmonowicz,Bettina M. Weigand,Ayush D. Patel,Tamar Pirtskhalava,Christine Inman,Kurt O. Johnson,Stephanie L. Dickinson,Azucena Rocha,Marissa J. Schafer,Yi Zhu,David B. Allison,Thomas von Zglinicki,Nathan K. LeBrasseur,Tamar Tchkonia,Nicola Neretti,João F. Passos,James L. Kirkland,Diana Jurk +22 more
TL;DR: In this article, an age-dependent increase in p16Ink4a senescent cells was observed in microglia and oligodendrocyte progenitor cells and characterized by a pro-inflammatory senescence-associated secretory phenotype (SASP).
Journal ArticleDOI
Temporal inhibition of autophagy reveals segmental reversal of ageing with increased cancer risk
Liam D. Cassidy,Andrew R. J. Young,Christopher N. J. Young,Elizabeth J. Soilleux,Edward Fielder,Bettina M. Weigand,Bettina M. Weigand,Anthony B. Lagnado,Rebecca Brais,Nicholas T. Ktistakis,Kimberley A. Wiggins,Katerina Pyrillou,Murray C.H. Clarke,Diana Jurk,João F. Passos,João F. Passos,Masashi Narita,Masashi Narita +17 more
TL;DR: It is demonstrated in murine models that the inhibition of Atg5 induces ageing phenotypes and reduces lifespan, whilst autophagy restoration partially reverses these phenotypes with accelerated tumorigenesis, and uncovers a biphasic role in cancer development being both tumour suppressive and oncogenic, sequentially.