H
Hajrunisa Cubro
Researcher at Mayo Clinic
Publications - 15
Citations - 1789
Hajrunisa Cubro is an academic researcher from Mayo Clinic. The author has contributed to research in topics: Preeclampsia & Adipose tissue. The author has an hindex of 7, co-authored 13 publications receiving 1016 citations. Previous affiliations of Hajrunisa Cubro include University of Louisville.
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Journal ArticleDOI
Senolytics improve physical function and increase lifespan in old age
Ming Xu,Ming Xu,Tamar Pirtskhalava,Joshua N. Farr,Bettina M. Weigand,Bettina M. Weigand,Allyson K. Palmer,Megan M. Weivoda,Christina L. Inman,Mikolaj Ogrodnik,Mikolaj Ogrodnik,Christine M Hachfeld,Daniel G. Fraser,Jennifer L Onken,Kurt O. Johnson,Grace C Verzosa,Larissa G.P. Langhi,Moritz Weigl,Nino Giorgadze,Nathan K. LeBrasseur,Jordan D. Miller,Diana Jurk,Ravinder J. Singh,David B. Allison,David B. Allison,Keisuke Ejima,Keisuke Ejima,Gene B. Hubbard,Yuji Ikeno,Yuji Ikeno,Hajrunisa Cubro,Vesna D. Garovic,Xiaonan Hou,S. John Weroha,Paul D. Robbins,Laura J. Niedernhofer,Sundeep Khosla,Tamara Tchkonia,James L. Kirkland +38 more
TL;DR: It is demonstrated that transplanting relatively small numbers of senescent cells into young mice is sufficient to cause persistent physical dysfunction, as well as to spread cellular senescence to host tissues, and a senolytic can reverse this dysfunction and potently increase lifespan in aged mice.
Journal ArticleDOI
Targeting senescent cells alleviates obesity‐induced metabolic dysfunction
Allyson K. Palmer,Ming Xu,Ming Xu,Yi Zhu,Tamar Pirtskhalava,Megan M. Weivoda,Christine M Hachfeld,Larissa G.P. Langhi Prata,Theo H. van Dijk,Esther Verkade,Grace Casaclang-Verzosa,Kurt O. Johnson,Hajrunisa Cubro,Ewald J. Doornebal,Mikolaj Ogrodnik,Mikolaj Ogrodnik,Diana Jurk,Diana Jurk,Michael D. Jensen,Eduardo N. Chini,Jordan D. Miller,Aleksey V. Matveyenko,Michael B. Stout,Marissa J. Schafer,Thomas A. White,La Tonya J. Hickson,Marco Demaria,Marco Demaria,Vesna D. Garovic,Joseph P. Grande,Edgar A. Arriaga,Folkert Kuipers,Thomas von Zglinicki,Nathan K. LeBrasseur,Judith Campisi,Tamar Tchkonia,James L. Kirkland +36 more
TL;DR: It is shown that reducing senescent cell burden in obese mice, either by activating drug‐inducible “suicide” genes driven by the p16Ink4a promoter or by treatment with senolytic agents, alleviates metabolic and adipose tissue dysfunction and that emerging senolytics agents hold promise for treating obesity‐related metabolic dysfunction and its complications.
Journal ArticleDOI
Early Onset Preeclampsia Is Associated With Glycocalyx Degradation and Reduced Microvascular Perfusion.
Tracey L. Weissgerber,Oscar Garcia-Valencia,Natasa Milic,Natasa Milic,Elizabeth Codsi,Hajrunisa Cubro,Meryl C. Nath,Wendy M. White,Karl A. Nath,Vesna D. Garovic +9 more
TL;DR: Glycocalyx degradation and reduced microvascular perfusion are associated with endothelial dysfunction and activation and vascular injury in early onset preeclampsia.
Journal ArticleDOI
Targeting senescence improves angiogenic potential of adipose-derived mesenchymal stem cells in patients with preeclampsia.
Sonja Suvakov,Hajrunisa Cubro,Wendy M. White,Yvonne S. Butler Tobah,Tracey L. Weissgerber,Kyra L. Jordan,Xiang Y. Zhu,John R. Woollard,Fouad T. Chebib,Natasa Milic,Natasa Milic,Joseph P. Grande,Ming Xu,Tamara Tchkonia,James L. Kirkland,Lilach O. Lerman,Vesna D. Garovic +16 more
TL;DR: The data suggest that MSC senescence exerts inhibitory effects on angiogenesis in preeclampsia andSenolytic agents may offer the opportunity for mechanism-based therapies.
Journal ArticleDOI
The Role of Interleukin-10 in the Pathophysiology of Preeclampsia
TL;DR: The significance of IL-10 in preeclampsia has shifted from a key biomarker to one with therapeutic potential and a better understanding of the role of this cytokine in the pathophysiology of preeClampsia is of paramount importance.