Showing papers in "The Journal of Allergy and Clinical Immunology: In Practice in 2021"
TL;DR: The U.S. Food and Drug Administration (FDA) has recently issued an Emergency Use Authorization (EUA) for 2 highly effective coronavirus disease 2019 (COVID-19) vaccines from Pfizer-BioNTech and Moderna.
311 citations
TL;DR: An algorithm is proposed to safely investigate suspected PEG allergy, with guidance on PEG molecular weights and skin test dilutions to minimize the risk of SAR.
149 citations
University of Colorado Denver1, University of Manitoba2, Dartmouth–Hitchcock Medical Center3, McMaster University4, University of Texas Southwestern Medical Center5, University of Michigan6, University of Ottawa7, University of Manchester8, Montreal Children's Hospital9, University of Cincinnati10, University of Rochester11, Children's Hospital at Westmead12, Mayo Clinic13, University of British Columbia14, I.M. Sechenov First Moscow State Medical University15, Cincinnati Children's Hospital Medical Center16, Queen's University17, Guy's and St Thomas' NHS Foundation Trust18, National Institutes of Health19, Ohio State University20, Washington University in St. Louis21, Royal College of Surgeons in Ireland22, Campbelltown Hospital23, Scripps Health24, Cleveland Clinic25, University of South Florida26, University of Cape Town27, University of Tennessee Health Science Center28, Boston Children's Hospital29, NorthShore University HealthSystem30, Rutgers University31, Royal Children's Hospital32, University of Western Ontario33, Kaiser Permanente34, University of Pennsylvania35, University of Nebraska–Lincoln36, Imperial College Healthcare37, Nova Southeastern University38, Icahn School of Medicine at Mount Sinai39, Humboldt University of Berlin40, University of Alberta41, Johns Hopkins University School of Medicine42
TL;DR: In this article, a multidisciplinary group of international experts in anaphylaxis composed of allergy, infectious disease, emergency medicine, and front-line clinicians to systematically develop recommendations regarding SARS-CoV-2 vaccine immediate allergic reactions.
131 citations
TL;DR: To prevent peanut and/or egg allergy, both peanut and egg should be introduced around 6 months of life, but not before 4 months, and infants should be fed a diverse diet, because this may help foster prevention of food allergy.
124 citations
TL;DR: The underlying systemic inflammatory link between CRSwNP and asthma provides a compelling rationale for systemic treatment with novel biologics targeting shared underlying type 2 inflammatory pathways.
112 citations
TL;DR: In this article, the authors identify risk factors associated with admission and subsequent mortality among COVID-19-infected asthmatics, including pre-existing eosinophilia (AEC ≥150 cells/μL) was associated with decreased mortality.
106 citations
104 citations
TL;DR: Great variability in the prevalence of comorbid asthma among COVID-19 patients in different countries or regions is found and asthmatic patients are found to have lower risk of death compared with non-asthmatic patients.
98 citations
TL;DR: In this paper, the authors assessed outcomes associated with excipient skin testing after a reported allergic reaction to the first dose of mRNA COVID-19 vaccine, and found that most individuals with a reported adverse reaction, regardless of skin test result, received the second dose safely.
97 citations
TL;DR: The 2013 United States Hereditary Angioedema Association Medical Advisory Board (US HAEA MAB) guidelines for the treatment and management of HAE are updated and extended, based on a comprehensive literature review.
91 citations
TL;DR: After 2 years of anti-IL-5 treatment, a favorable response was found in 83% of severe asthma patients, including a super-response in 14%, and tended to be associated with adult-onset asthma, absence of nasal polyps and lower BMI.
University of Paris1, Necker-Enfants Malades Hospital2, French Institute of Health and Medical Research3, École normale supérieure de Lyon4, Pasteur Institute5, Boston Children's Hospital6, University of Paris-Sud7, University of Lausanne8, Katholieke Universiteit Leuven9, Manchester Academic Health Science Centre10, Collège de France11, University of Edinburgh12
TL;DR: This largest worldwide cohort of SAVI patients precise core features are described and extends the clinical and immunological phenotype of the disease, displaying overlap with other monogenic interferonopathies.
TL;DR: Benralizumab was well tolerated, facilitated oral corticosteroid reduction and reduced exacerbations in EGPA, and larger controlled trials are warranted to further evaluate the role of benralIZumab in EGpa.
TL;DR: Lower COVID-19 susceptibility in patients with pre-existing asthma is observed in this retrospective population-based cross-sectional study utilizing data from a large nation-wide health maintenance organization (HMO) in Israel.
TL;DR: Asthma and COPD are not risk factors for ICU admission and death related to SARS-CoV2 infection, and the multivariate analysis showed that asthma, COPD, ICS treatment and OCS treatment were not independentrisk factors forICU admission or death.
Woolcock Institute of Medical Research1, Monroe Carell Jr. Children's Hospital at Vanderbilt2, University of Cape Town3, University of Leicester4, Ghent University Hospital5, University of Mainz6, Federal University of Bahia7, Erasmus University Rotterdam8, Harvard University9, University of British Columbia10, Imperial College London11, Kagoshima University12, The Chinese University of Hong Kong13, University of Illinois at Chicago14, Laval University15, China-Japan Friendship Hospital16, Liverpool School of Tropical Medicine17, University of Edinburgh18, Celal Bayar University19
TL;DR: The Global Initiative for Asthma (GINA) Strategy Report provides clinicians with an annually updated evidence-based strategy for asthma management and prevention, which can be adapted for local circumstances (e.g., medication availability) as discussed by the authors.
Sapienza University of Rome1, University of Brescia2, University of Naples Federico II3, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico4, University of Padua5, University of Florence6, Boston Children's Hospital7, University of Rome Tor Vergata8, University of Bologna9, University of Bari10, University of Cagliari11, Policlinico Umberto I12, Marche Polytechnic University13, Vita-Salute San Raffaele University14
TL;DR: In this article, the authors survey severe asthma experts using a modified Delphi process, to develop an international consensus-based definition of a severe asthma superresponder (SR) which is an important prerequisite for better understanding severe asthma prevalence, predictive factors, and the mechanisms involved.
TL;DR: In this article, the authors discuss clinically relevant cross-reactivity related to the aforementioned food groups as well as seeds, legumes (including peanut, soy, chickpea, lentil, and others), tree nuts, meats, fruits and vegetables (including the lipid transfer protein syndrome), and latex.
TL;DR: In this article, the authors reviewed the mechanisms, safety, and efficacy of dupilumab from recent clinical trials, and reviewed the current data, mechanism of action, clinical efficacy, and limitations of new biologics currently in phase 2 and 3 clinical trials.
TL;DR: The majority of patients with severe asthma showed at least one T2 inflammatory trait, and co-expression of T2 biomarkers was highly heterogeneous, and different expression patterns were associated with distinct clinical characteristics.
TL;DR: In this article, the authors performed an indirect treatment comparison (ITC) of the efficacy of biologics plus INCS versus placebo (INCS) as a common comparator for patients with chronic rhinosinusitis with nasal polyps.
TL;DR: In this article, the authors review the predictive value of different tests used to support the diagnosis of food allergy, discuss implications for therapy and prognosis, and propose a diagnostic approach to be applied in clinical practice.
TL;DR: In this paper, the authors reviewed the current understanding of the pathogenesis of chronic spontaneous urticaria and its autoimmune endotypes and provided updated information and guidance on the use of biologics in the treatment of patients with CSU, now and in the near future.
TL;DR: Patient self-monitoring via a digital platform plus remote clinician feedback, maintained high baseline ICS adherence and decreased SABA use.
TL;DR: In this article, a meta-analysis evaluated real-world data of omalizumab on treatment response, lung function, exacerbations, oral corticosteroid (OCS) use, patient-reported outcomes (PROs), health care resource utilization (HCRU), and school/work absenteeism at 4, 6, and 12 months after treatment.
TL;DR: Clinical examples, up-to-date knowledge of hereditary α-tryptasemia as a frequent cause of baseline tryptase of 7 μg/L and higher, mastocytosis, other clonal myeloid disorders, cardiovascular or renal failure, and technical improvements resulting in continued lowering of the 95th percentile value are discussed.