L
Laura E. Benjamin
Researcher at Beth Israel Deaconess Medical Center
Publications - 52
Citations - 9242
Laura E. Benjamin is an academic researcher from Beth Israel Deaconess Medical Center. The author has contributed to research in topics: Angiogenesis & Protein kinase B. The author has an hindex of 33, co-authored 44 publications receiving 8568 citations. Previous affiliations of Laura E. Benjamin include Eli Lilly and Company & Harvard University.
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Journal ArticleDOI
Tumorigenesis and the angiogenic switch
TL;DR: A more detailed understanding of the complex parameters that govern the interactions between the tumour and vascular compartments will help to improve anti-angiogenic strategies — not only for cancer treatment, but also for preventing recurrence.
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Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis
Yingdi Wang,Masanori Nakayama,Mara E. Pitulescu,Tim S. Schmidt,Magdalena L. Bochenek,Magdalena L. Bochenek,Akira Sakakibara,Susanne Adams,Susanne Adams,Alice Davy,Urban Deutsch,Urs Lüthi,Alcide Barberis,Laura E. Benjamin,Taija Makinen,Catherine D. Nobes,Ralf H. Adams,Ralf H. Adams +17 more
TL;DR: It is shown with genetic experiments in mouse and zebrafish that ephrin-B2, a transmembrane ligand for Eph receptor tyrosine kinases, promotes sprouting behaviour and motility in the angiogenic endothelium, and shows that full VEGFR3 signalling is coupled to receptor internalization.
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Vascular permeability, vascular hyperpermeability and angiogenesis
TL;DR: It is demonstrated that three distinctly different types of vascular permeability can be distinguished, based on the differenttypes of microvessels involved, the composition of the extravasate, and the anatomic pathways by which molecules of different size cross-vascular endothelium mediate.
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Vascular Permeability Factor/Vascular Endothelial Growth Factor Induces Lymphangiogenesis as well as Angiogenesis
Janice A. Nagy,Eliza Vasile,Dian Feng,Christian Sundberg,Lawrence F. Brown,Michael Detmar,Joel A. Lawitts,Laura E. Benjamin,Xiaolian Tan,Eleanor J. Manseau,Ann M. Dvorak,Harold F. Dvorak +11 more
TL;DR: It is reported that, in addition to inducing angiogenesis, VEGF-A164 also induces a strong lymphangiogenic response, which raises the possibility that similar, abnormal lymphatics develop in other pathologies in which VEGf-A is overexpressed, e.g., malignant tumors and chronic inflammation.
Journal ArticleDOI
Pathological angiogenesis is induced by sustained Akt signaling and inhibited by rapamycin
Thuy L. Phung,Keren Ziv,Donnette Dabydeen,Godfred Eyiah-Mensah,Marcela Riveros,Carole A. Perruzzi,Jingfang Sun,Rita A. Monahan-Earley,Ichiro Shiojima,Janice A. Nagy,Michelle I. Lin,Kenneth Walsh,Ann M. Dvorak,David M. Briscoe,Michal Neeman,William C. Sessa,Harold F. Dvorak,Laura E. Benjamin +17 more
TL;DR: In this paper, rapamycin inhibited endothelial Akt signaling, vascular changes from myrAkt1, tumor growth, and tumor vascular permeability in growing tumors, demonstrating an ongoing requirement for Akt signalling for the maintenance of these phenotypes.