Urs Lüthi

TL;DR: It is shown with genetic experiments in mouse and zebrafish that ephrin-B2, a transmembrane ligand for Eph receptor tyrosine kinases, promotes sprouting behaviour and motility in the angiogenic endothelium, and shows that full VEGFR3 signalling is coupled to receptor internalization.

TL;DR: Interestingly, homology between animal and plant p300/CBP is largely restricted to a C-terminal segment, about 600 amino acids in length, which encompasses acetyltransferase and E1A-binding domains.

TL;DR: Unexpectedly, it is found that the PHD finger of p300, but not of CBP, is dispensable for AT activity, which provides evidence for structural differences between p300 and CBP that may in part underlie a previously reported functional specialization of the two proteins.

TL;DR: An in silico screening approach consisting of fragment-based docking, ligand conformational search by a genetic algorithm, and evaluation of free energy of binding was used to identify low-molecular-weight inhibitors of BACE-1, which has emerged as an important but difficult protein target.

TL;DR: The phenylureathiadiazole 2 and the diphenylurea derivative 3 are promising lead compounds for beta-secretase inhibition.